Pulse NMR study of structural characteristics of temperature-sensitive hydrogel

R. Roger Ruan, Jun Han, Paul L. Chen, Blanca C. Martinez

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


The proton relaxation behavior of a temperature-sensitive gel, observed through using a pulse NMR technique, was related to the structural characteristics of the gel. As the temperature increased, the pore size of the gel decreased gradually while the relaxation time constants, T1 and T2, showed different patterns of change. It is believed that the proton relaxation was affected by a direct temperature effect and an indirect, temperature-related structural effect. The response of the protons to these effects varied depending on where the protons resided. A sudden increase in several NMR parameter values occurred at around 30°C, the lower critical solution temperature (LCST). This may be related to a transition state of the gel undergoing dramatic local non-uniform changes around the LCST.

Original languageEnglish (US)
Pages (from-to)257-260
Number of pages4
JournalBiotechnology Techniques
Issue number4
StatePublished - 1997


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