Pulsatilloside A and anemoside A3 protect PC12 cells from apoptosis induced by sodium cyanide and glucose deprivation

Xiang Dong Gao; Wen Cai Ye; Albert C.H. Yu; Yun Zhang; Ren Xiang Tan; Ming Li; W. L.Wendy Hsiao

doi:10.1055/s-2003-37705

Pulsatilloside A and anemoside A₃ protect PC12 cells from apoptosis induced by sodium cyanide and glucose deprivation

Xiang Dong Gao, Wen Cai Ye, Albert C.H. Yu, Yun Zhang, Ren Xiang Tan, Ming Li, W. L.Wendy Hsiao

Biochemistry, Molecular Biology, and Biophysics (CBS)

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19 Scopus citations

Abstract

Using sodium cyanide (NaCN) and glucose deprivation induced cell injury in PC12 as an injury model, we investigated the protective effects of pulsatilloside A and anemoside A₃ on neurons. The results showed that PC12 cells under the NaCN-injury and glucose deprivation would undergo apoptosis. Additions of pulsatilloside A and anemoside A₃, at dosages ranging from 0.1, 1 and 10μg/ml, protected PC12 cells from apoptosis determined by MTT, LDH release analysis, and flow cytometry measurement.

Original language	English (US)
Pages (from-to)	171-174
Number of pages	4
Journal	Planta Medica
Volume	69
Issue number	2
DOIs	https://doi.org/10.1055/s-2003-37705
State	Published - Feb 1 2003

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10.1055/s-2003-37705

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title = "Pulsatilloside A and anemoside A3 protect PC12 cells from apoptosis induced by sodium cyanide and glucose deprivation",

abstract = "Using sodium cyanide (NaCN) and glucose deprivation induced cell injury in PC12 as an injury model, we investigated the protective effects of pulsatilloside A and anemoside A3 on neurons. The results showed that PC12 cells under the NaCN-injury and glucose deprivation would undergo apoptosis. Additions of pulsatilloside A and anemoside A3, at dosages ranging from 0.1, 1 and 10μg/ml, protected PC12 cells from apoptosis determined by MTT, LDH release analysis, and flow cytometry measurement.",

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AU - Gao, Xiang Dong

AU - Ye, Wen Cai

AU - Yu, Albert C.H.

AU - Zhang, Yun

AU - Tan, Ren Xiang

AU - Li, Ming

AU - Hsiao, W. L.Wendy

PY - 2003/2/1

Y1 - 2003/2/1

N2 - Using sodium cyanide (NaCN) and glucose deprivation induced cell injury in PC12 as an injury model, we investigated the protective effects of pulsatilloside A and anemoside A3 on neurons. The results showed that PC12 cells under the NaCN-injury and glucose deprivation would undergo apoptosis. Additions of pulsatilloside A and anemoside A3, at dosages ranging from 0.1, 1 and 10μg/ml, protected PC12 cells from apoptosis determined by MTT, LDH release analysis, and flow cytometry measurement.

AB - Using sodium cyanide (NaCN) and glucose deprivation induced cell injury in PC12 as an injury model, we investigated the protective effects of pulsatilloside A and anemoside A3 on neurons. The results showed that PC12 cells under the NaCN-injury and glucose deprivation would undergo apoptosis. Additions of pulsatilloside A and anemoside A3, at dosages ranging from 0.1, 1 and 10μg/ml, protected PC12 cells from apoptosis determined by MTT, LDH release analysis, and flow cytometry measurement.

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Pulsatilloside A and anemoside A₃ protect PC12 cells from apoptosis induced by sodium cyanide and glucose deprivation

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