Pulmonary vascular effects of amrinone in conscious lambs

Mark C Mammel, Stanley Einzig, Thomas J. Kulik, Theodore R. Thompson, James E. Lock

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Summary The direct pulmonary vascular effects of amrinone, a nongly-coside, noncatechole cardiotonic agent were studied in conscious newborn lambs using a double-flow probe preparation that allows separation of direct and indirect pulmonary vascular effects. Amrinone was found to be a direct pulmonary vasodilator with a threshold dose of 0.3 mg/kg. Amrinone also increased cardiac output and decreased aortic pressure at somewhat higher threshold doses (1.0 mg/kg and 3.0 mg/kg, respectively). Amrinone’s peak effect on pulmonary resistance appeared greater than its peak systemic effects. These effects were noted in both normoxia and hypoxia, and were not changed by pretreatment with propranolol.

Original languageEnglish (US)
Pages (from-to)720-724
Number of pages5
JournalPediatric Research
Issue number9
StatePublished - Sep 1983


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