This report describes a patient who developed pulmonary toxicity, manifest by dyspnea on exertion, a low pO2, a normal FEV1 and FVC, and a low DLCO while receiving 5-fluoro-2'-deoxyuridine (FUDR) by intermittent continuous i.v. infusion. No other cause of his low DLCO could be identified. The dyspnea on exertion and DLCO improved gradually after the FUDR was discontinued. This case was felt to represent a previously undescribed toxicity of the continuous i.v. infusion of FUDR.
- infusional y toxicity
- renal cell cancer