TY - JOUR
T1 - Pulmonary perfusion during lung transplant rejection and experimental pneumonia
AU - Santillan-Doherty, Patrick
AU - Jasso-Victoria, Rogelio
AU - Sotres-Vega, Avelina
AU - Arreola, Josè L.
AU - Olmos, Raul
AU - Andrade, Rafael
AU - Villalba, Jaime
AU - Sada, Eduardo
AU - Coo, Juan
AU - Papadakis, Miguel
PY - 1992/3
Y1 - 1992/3
N2 - Six left lung allotransplants were performed in healthy mongrel dogs. Immunosuppression was established with cyclosporine (15 mg/kg/day p.o.) from the day of transplantation for 30 days. Another group of animals (n=3) was used to produce acute experimental pneumonia by instilling 4—6 ml of a 108 CFU suspension of P8eudomonas aeruginosa into the right lower lobe. Dynamic perfusory lung scintigraphy (DPLS) was performed before transplant/pneumonia (control), during acute rejection/pneumonia as detected radiologically, and after treatment with methylprednisolone (1 g/day for 3 days i.v.) (transplant group) or antibiotics (pneumonia group). Seroalbumin macroaggregates (5-8 Mcl) marked with 99-mTc were injected into the cephalic vein and the percentage of perfusion to each lung was determined. Eight acute rejection episodes were detected. DPLS showed similar perfusion to each lung, whereas during acute rejection perfusion was significantly reduced by almost 30%. Perfusion was reestablished to control levels after treatment with methylprednisolone. Reduction in perfusion correlated with radiological rejection grading. No reduction in left lung perfusion was detected in pneumonia animals. In conclusion, acute rejection reduces perfusion to the transplanted lung as measured by DPLS. Treatment restores normal perfusion.
AB - Six left lung allotransplants were performed in healthy mongrel dogs. Immunosuppression was established with cyclosporine (15 mg/kg/day p.o.) from the day of transplantation for 30 days. Another group of animals (n=3) was used to produce acute experimental pneumonia by instilling 4—6 ml of a 108 CFU suspension of P8eudomonas aeruginosa into the right lower lobe. Dynamic perfusory lung scintigraphy (DPLS) was performed before transplant/pneumonia (control), during acute rejection/pneumonia as detected radiologically, and after treatment with methylprednisolone (1 g/day for 3 days i.v.) (transplant group) or antibiotics (pneumonia group). Seroalbumin macroaggregates (5-8 Mcl) marked with 99-mTc were injected into the cephalic vein and the percentage of perfusion to each lung was determined. Eight acute rejection episodes were detected. DPLS showed similar perfusion to each lung, whereas during acute rejection perfusion was significantly reduced by almost 30%. Perfusion was reestablished to control levels after treatment with methylprednisolone. Reduction in perfusion correlated with radiological rejection grading. No reduction in left lung perfusion was detected in pneumonia animals. In conclusion, acute rejection reduces perfusion to the transplanted lung as measured by DPLS. Treatment restores normal perfusion.
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U2 - 10.1097/00007890-199203000-00007
DO - 10.1097/00007890-199203000-00007
M3 - Article
C2 - 1549843
AN - SCOPUS:0026524378
SN - 0041-1337
VL - 53
SP - 533
EP - 535
JO - Transplantation
JF - Transplantation
IS - 3
ER -