Pulmonary Mycobacterium Spindle Cell Pseudotumor in Patient With Liver Transplant

Supavit Chesdachai, Prowpanga Udompap, Faqian Li, John R. Lake, Mandip KC

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


We report a case of liver transplant patient who presented with lung masses, found to be Mycobacterium spindle cell pseudotumors. The masses demonstrated hypermetabolic activities on positron emission tomography. Core biopsy revealed sheets of spindle histiocytic cells with abundant acid-fast bacilli identified as Mycobacterium avium-intracellulare complex. This finding is a rare presentation of Mycobacterium infection, mainly nontuberculous Mycobaterium. It is characterized by a benign, spindle cell mass-forming reaction. Most of the reported cases had acquired immune deficiency syndrome or organ transplant. Histopathology illustrating the proliferation of spindle cell shaped histiocytes containing numerous acid-fast bacilli is the gold standard for diagnosis. The standard treatment has not been well established; previously reported cases followed the standard treatment for Mycobacterium based on organ involvement. Our case is the first case to our knowledge that reports pulmonary Mycobacterium spindle cell pseudotumors in a liver transplant recipient.

Original languageEnglish (US)
Pages (from-to)42-50
Number of pages9
JournalAmerican Journal of the Medical Sciences
Issue number1
StatePublished - Jan 2020

Bibliographical note

Publisher Copyright:
© 2019 Southern Society for Clinical Investigation


  • Liver transplantation
  • Mycobacterium avium-intracellulare
  • Spindle cell tumor


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