Pulmonary Dysfunction in Hemodialysis

Philip R. Craddock, Harry S. Jacob, Kenneth L. Brigham, Nicholas M. Aurigemma, Neil T. Feldman, Michael Gottlieb, Roland H. Ingram, J. Michael Lazarus, Edmund G. Lowrie

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To the Editor: The brief article by Aurigemma et al. (N Engl J Med 297:871, 1977) demonstrates that arterial hypoxemia may occur during hemodialysis because of hypoventilation induced by carbon dioxide loss from dialysis baths. We are uncertain whether the authors would conclude from their data that pulmonary dysfunction does not occur during dialysis. We hope not, since we have demonstrated1 diminished carbon monoxide diffusion capacity and increased closing volumes in patients and striking pulmonary hypertension with doubling of pulmonary-artery pressures, and highprotein pulmonary edema with concomitant increased lymph flow, in animals simply reinfused with plasma exposed to dialyzer cellophane.

Original languageEnglish (US)
Pages (from-to)283
Number of pages1
JournalNew England Journal of Medicine
Issue number5
StatePublished - Feb 2 1978

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    Craddock, P. R., Jacob, H. S., Brigham, K. L., Aurigemma, N. M., Feldman, N. T., Gottlieb, M., Ingram, R. H., Lazarus, J. M., & Lowrie, E. G. (1978). Pulmonary Dysfunction in Hemodialysis. New England Journal of Medicine, 298(5), 283. https://doi.org/10.1056/NEJM197802022980522