Pulmonary Carcinoma with Eosinophilia: Demonstration of a Tumor-Derived Eosinophilopoietic Factor

Arne Slungaard, Joao Ascensao, Esmail Zanjani, Harry S. Jacob

Research output: Contribution to journalArticlepeer-review

77 Scopus citations

Abstract

A WIDE variety of solid and hematologic cancers are occasionally accompanied by peripheral-blood eosinophilia,1 but the mechanisms underlying this curious relationship remain obscure. To elucidate one mechanism that may account for cancer-associated eosinophilia, we studied a patient whose waxing and waning pulmonary carcinoma closely paralleled a striking eosinophilic leukemoid reaction. This association led us to hypothesize that the tumor was producing and secreting a hematopoietically active factor that stimulated bone-marrow production of eosinophils. We sought to demonstrate and characterize this putative “eosinophilopoietic” factor in the patient's tumor and serum. We found that even in high dilutions, a buffered saline extract.

Original languageEnglish (US)
Pages (from-to)778-781
Number of pages4
JournalNew England Journal of Medicine
Volume309
Issue number13
DOIs
StatePublished - Sep 29 1983

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