Pulmonary Blood Volume Among Older Adults in the Community: The MESA Lung Study

Emilia A. Hermann; Amin Motahari; Eric A. Hoffman; Norrina Allen; Alain G. Bertoni; David A. Bluemke; Ali Eskandari; Sarah E. Gerard; Junfeng Guo; Grant T. Hiura; David W. Kaczka; Erin D. Michos; Prashant Nagpal; Jim Pankow; Sanjiv Shah; Benjamin M. Smith; Karen Hinckley Stukovsky; Yifei Sun; Karol Watson; R. Graham Barr

doi:10.1161/CIRCIMAGING.122.014380

Pulmonary Blood Volume Among Older Adults in the Community: The MESA Lung Study

Emilia A. Hermann, Amin Motahari, Eric A. Hoffman, Norrina Allen, Alain G. Bertoni, David A. Bluemke, Ali Eskandari, Sarah E. Gerard, Junfeng Guo, Grant T. Hiura, David W. Kaczka, Erin D. Michos, Prashant Nagpal, Jim Pankow, Sanjiv Shah, Benjamin M. Smith, Karen Hinckley Stukovsky, Yifei Sun, Karol Watson, R. Graham Barr

Epidemiology & Community Health

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

BACKGROUND: The pulmonary vasculature is essential for gas exchange and impacts both pulmonary and cardiac function. However, it is difficult to assess and its characteristics in the general population are unknown. We measured pulmonary blood volume (PBV) noninvasively using contrast enhanced, dual-energy computed tomography to evaluate its relationship to age and symptoms among older adults in the community.

METHODS: The MESA (Multi-Ethnic Study of Atherosclerosis) is an ongoing community-based, multicenter cohort. All participants attending the most recent MESA exam were selected for contrast enhanced dual-energy computed tomography except those with estimated glomerular filtration rate <60 mL/min per 1.73 m 2. PBV was calculated by material decomposition of dual-energy computed tomography images. Multivariable models included age, sex, race/ethnicity, education, height, weight, smoking status, pack-years, and scanner model.

RESULTS: The mean age of the 727 participants was 71 (range 59-94) years, and 55% were male. The race/ethnicity distribution was 41% White, 29% Black, 17% Hispanic, and 13% Asian. The mean±SD PBV in the youngest age quintile was 547±180 versus 433±194 mL in the oldest quintile ( P<0.001), with an approximately linear decrement of 50 mL per 10 years of age ([95% CI, 32-67]; P<0.001). Findings were similar with multivariable adjustment. Lower PBV was associated independently with a greater dyspnea after a 6-minute walk ( P=0.04) and greater composite dyspnea symptom scores ( P=0.02). Greater PBV was also associated with greater height, weight, lung volume, Hispanic race/ethnicity, and nonsmoking history.

CONCLUSIONS: Pulmonary blood volume was substantially lower with advanced age and was associated independently with greater symptoms scores in the elderly.

Original language	English (US)
Pages (from-to)	E014380
Journal	Circulation: Cardiovascular Imaging
Volume	15
Issue number	8
DOIs	https://doi.org/10.1161/CIRCIMAGING.122.014380
State	Published - Aug 1 2022

Bibliographical note

Funding Information:
Dr Hoffman is a founder and shareholder of VIDA Diagnostics, which makes the software used for secondary (percent emphysema) but not primary (PBV) measures in this article. Dr Kaczka acknowledges grant support from the US Department of Defense and ZOLL Medical Corporation, for work unrelated to this study, is as a paid consultant to Lungpacer Medical, Inc, is a co-founder and shareholder of OscillaVent, Inc and is listed as a co-inventor on United States and European patents related to multi-frequency oscillatory ventilation. Dr Guo is a shareholder of VIDA Diagnostics. Unrelated to this work, Dr Michos reports advisory boards for AstraZeneca, Amarin, Bayer, Esperion, Novartis, and Novo Nordisk.

Funding Information:
This publication was supported by NIH/National Heart, Lung, and Blood Institute R01-HL077612, R01-HL093081, R01-HL130506, N01-HC-95159 through N01-HC-95165, N01-HC-95169 and the National Center for Advancing Translational Sciences (Grant Number UL1 TR000040).

Publisher Copyright:
© 2022 Lippincott Williams and Wilkins. All rights reserved.

Keywords

aging
blood volume
physiology
pulmonary circulation
tomography
Lung/diagnostic imaging
Tomography, X-Ray Computed/methods
Humans
Middle Aged
Male
Dyspnea
Aged, 80 and over
Blood Volume
Female
Aged
Cohort Studies

PubMed: MeSH publication types

Multicenter Study
Journal Article
Research Support, N.I.H., Extramural

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10.1161/CIRCIMAGING.122.014380

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Hermann, E. A., Motahari, A., Hoffman, E. A., Allen, N., Bertoni, A. G., Bluemke, D. A., Eskandari, A., Gerard, S. E., Guo, J., Hiura, G. T., Kaczka, D. W., Michos, E. D., Nagpal, P., Pankow, J., Shah, S., Smith, B. M., Hinckley Stukovsky, K., Sun, Y., Watson, K., & Graham Barr, R. (2022). Pulmonary Blood Volume Among Older Adults in the Community: The MESA Lung Study. Circulation: Cardiovascular Imaging, 15(8), E014380. https://doi.org/10.1161/CIRCIMAGING.122.014380

Hermann, EA, Motahari, A, Hoffman, EA, Allen, N, Bertoni, AG, Bluemke, DA, Eskandari, A, Gerard, SE, Guo, J, Hiura, GT, Kaczka, DW, Michos, ED, Nagpal, P, Pankow, J, Shah, S, Smith, BM, Hinckley Stukovsky, K, Sun, Y, Watson, K & Graham Barr, R 2022, 'Pulmonary Blood Volume Among Older Adults in the Community: The MESA Lung Study', Circulation: Cardiovascular Imaging, vol. 15, no. 8, pp. E014380. https://doi.org/10.1161/CIRCIMAGING.122.014380

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title = "Pulmonary Blood Volume Among Older Adults in the Community: The MESA Lung Study",

abstract = "BACKGROUND: The pulmonary vasculature is essential for gas exchange and impacts both pulmonary and cardiac function. However, it is difficult to assess and its characteristics in the general population are unknown. We measured pulmonary blood volume (PBV) noninvasively using contrast enhanced, dual-energy computed tomography to evaluate its relationship to age and symptoms among older adults in the community.METHODS: The MESA (Multi-Ethnic Study of Atherosclerosis) is an ongoing community-based, multicenter cohort. All participants attending the most recent MESA exam were selected for contrast enhanced dual-energy computed tomography except those with estimated glomerular filtration rate <60 mL/min per 1.73 m 2. PBV was calculated by material decomposition of dual-energy computed tomography images. Multivariable models included age, sex, race/ethnicity, education, height, weight, smoking status, pack-years, and scanner model. RESULTS: The mean age of the 727 participants was 71 (range 59-94) years, and 55% were male. The race/ethnicity distribution was 41% White, 29% Black, 17% Hispanic, and 13% Asian. The mean±SD PBV in the youngest age quintile was 547±180 versus 433±194 mL in the oldest quintile ( P<0.001), with an approximately linear decrement of 50 mL per 10 years of age ([95% CI, 32-67]; P<0.001). Findings were similar with multivariable adjustment. Lower PBV was associated independently with a greater dyspnea after a 6-minute walk ( P=0.04) and greater composite dyspnea symptom scores ( P=0.02). Greater PBV was also associated with greater height, weight, lung volume, Hispanic race/ethnicity, and nonsmoking history. CONCLUSIONS: Pulmonary blood volume was substantially lower with advanced age and was associated independently with greater symptoms scores in the elderly.",

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author = "Hermann, {Emilia A.} and Amin Motahari and Hoffman, {Eric A.} and Norrina Allen and Bertoni, {Alain G.} and Bluemke, {David A.} and Ali Eskandari and Gerard, {Sarah E.} and Junfeng Guo and Hiura, {Grant T.} and Kaczka, {David W.} and Michos, {Erin D.} and Prashant Nagpal and Jim Pankow and Sanjiv Shah and Smith, {Benjamin M.} and {Hinckley Stukovsky}, Karen and Yifei Sun and Karol Watson and {Graham Barr}, R.",

note = "Funding Information: Dr Hoffman is a founder and shareholder of VIDA Diagnostics, which makes the software used for secondary (percent emphysema) but not primary (PBV) measures in this article. Dr Kaczka acknowledges grant support from the US Department of Defense and ZOLL Medical Corporation, for work unrelated to this study, is as a paid consultant to Lungpacer Medical, Inc, is a co-founder and shareholder of OscillaVent, Inc and is listed as a co-inventor on United States and European patents related to multi-frequency oscillatory ventilation. Dr Guo is a shareholder of VIDA Diagnostics. Unrelated to this work, Dr Michos reports advisory boards for AstraZeneca, Amarin, Bayer, Esperion, Novartis, and Novo Nordisk. Funding Information: This publication was supported by NIH/National Heart, Lung, and Blood Institute R01-HL077612, R01-HL093081, R01-HL130506, N01-HC-95159 through N01-HC-95165, N01-HC-95169 and the National Center for Advancing Translational Sciences (Grant Number UL1 TR000040). Publisher Copyright: {\textcopyright} 2022 Lippincott Williams and Wilkins. All rights reserved.",

year = "2022",

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day = "1",

doi = "10.1161/CIRCIMAGING.122.014380",

language = "English (US)",

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pages = "E014380",

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TY - JOUR

T1 - Pulmonary Blood Volume Among Older Adults in the Community

T2 - The MESA Lung Study

AU - Hermann, Emilia A.

AU - Motahari, Amin

AU - Hoffman, Eric A.

AU - Allen, Norrina

AU - Bertoni, Alain G.

AU - Bluemke, David A.

AU - Eskandari, Ali

AU - Gerard, Sarah E.

AU - Guo, Junfeng

AU - Hiura, Grant T.

AU - Kaczka, David W.

AU - Michos, Erin D.

AU - Nagpal, Prashant

AU - Pankow, Jim

AU - Shah, Sanjiv

AU - Smith, Benjamin M.

AU - Hinckley Stukovsky, Karen

AU - Sun, Yifei

AU - Watson, Karol

AU - Graham Barr, R.

N1 - Funding Information: Dr Hoffman is a founder and shareholder of VIDA Diagnostics, which makes the software used for secondary (percent emphysema) but not primary (PBV) measures in this article. Dr Kaczka acknowledges grant support from the US Department of Defense and ZOLL Medical Corporation, for work unrelated to this study, is as a paid consultant to Lungpacer Medical, Inc, is a co-founder and shareholder of OscillaVent, Inc and is listed as a co-inventor on United States and European patents related to multi-frequency oscillatory ventilation. Dr Guo is a shareholder of VIDA Diagnostics. Unrelated to this work, Dr Michos reports advisory boards for AstraZeneca, Amarin, Bayer, Esperion, Novartis, and Novo Nordisk. Funding Information: This publication was supported by NIH/National Heart, Lung, and Blood Institute R01-HL077612, R01-HL093081, R01-HL130506, N01-HC-95159 through N01-HC-95165, N01-HC-95169 and the National Center for Advancing Translational Sciences (Grant Number UL1 TR000040). Publisher Copyright: © 2022 Lippincott Williams and Wilkins. All rights reserved.

PY - 2022/8/1

Y1 - 2022/8/1

N2 - BACKGROUND: The pulmonary vasculature is essential for gas exchange and impacts both pulmonary and cardiac function. However, it is difficult to assess and its characteristics in the general population are unknown. We measured pulmonary blood volume (PBV) noninvasively using contrast enhanced, dual-energy computed tomography to evaluate its relationship to age and symptoms among older adults in the community.METHODS: The MESA (Multi-Ethnic Study of Atherosclerosis) is an ongoing community-based, multicenter cohort. All participants attending the most recent MESA exam were selected for contrast enhanced dual-energy computed tomography except those with estimated glomerular filtration rate <60 mL/min per 1.73 m 2. PBV was calculated by material decomposition of dual-energy computed tomography images. Multivariable models included age, sex, race/ethnicity, education, height, weight, smoking status, pack-years, and scanner model. RESULTS: The mean age of the 727 participants was 71 (range 59-94) years, and 55% were male. The race/ethnicity distribution was 41% White, 29% Black, 17% Hispanic, and 13% Asian. The mean±SD PBV in the youngest age quintile was 547±180 versus 433±194 mL in the oldest quintile ( P<0.001), with an approximately linear decrement of 50 mL per 10 years of age ([95% CI, 32-67]; P<0.001). Findings were similar with multivariable adjustment. Lower PBV was associated independently with a greater dyspnea after a 6-minute walk ( P=0.04) and greater composite dyspnea symptom scores ( P=0.02). Greater PBV was also associated with greater height, weight, lung volume, Hispanic race/ethnicity, and nonsmoking history. CONCLUSIONS: Pulmonary blood volume was substantially lower with advanced age and was associated independently with greater symptoms scores in the elderly.

AB - BACKGROUND: The pulmonary vasculature is essential for gas exchange and impacts both pulmonary and cardiac function. However, it is difficult to assess and its characteristics in the general population are unknown. We measured pulmonary blood volume (PBV) noninvasively using contrast enhanced, dual-energy computed tomography to evaluate its relationship to age and symptoms among older adults in the community.METHODS: The MESA (Multi-Ethnic Study of Atherosclerosis) is an ongoing community-based, multicenter cohort. All participants attending the most recent MESA exam were selected for contrast enhanced dual-energy computed tomography except those with estimated glomerular filtration rate <60 mL/min per 1.73 m 2. PBV was calculated by material decomposition of dual-energy computed tomography images. Multivariable models included age, sex, race/ethnicity, education, height, weight, smoking status, pack-years, and scanner model. RESULTS: The mean age of the 727 participants was 71 (range 59-94) years, and 55% were male. The race/ethnicity distribution was 41% White, 29% Black, 17% Hispanic, and 13% Asian. The mean±SD PBV in the youngest age quintile was 547±180 versus 433±194 mL in the oldest quintile ( P<0.001), with an approximately linear decrement of 50 mL per 10 years of age ([95% CI, 32-67]; P<0.001). Findings were similar with multivariable adjustment. Lower PBV was associated independently with a greater dyspnea after a 6-minute walk ( P=0.04) and greater composite dyspnea symptom scores ( P=0.02). Greater PBV was also associated with greater height, weight, lung volume, Hispanic race/ethnicity, and nonsmoking history. CONCLUSIONS: Pulmonary blood volume was substantially lower with advanced age and was associated independently with greater symptoms scores in the elderly.

KW - aging

KW - blood volume

KW - physiology

KW - pulmonary circulation

KW - tomography

KW - Lung/diagnostic imaging

KW - Tomography, X-Ray Computed/methods

KW - Humans

KW - Middle Aged

KW - Male

KW - Dyspnea

KW - Aged, 80 and over

KW - Blood Volume

KW - Female

KW - Aged

KW - Cohort Studies

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Pulmonary Blood Volume Among Older Adults in the Community: The MESA Lung Study

Abstract

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Keywords

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