Pulmonary blood vessels and endocrine cells in subacute infantile mountain sickness

D. Heath; P. Harris; G. J. Sui; Y. H. Liu; J. Gosney; E. Harris; I. S. Anand

doi:10.1016/S0954-6111(89)80064-2

Pulmonary blood vessels and endocrine cells in subacute infantile mountain sickness

D. Heath, P. Harris, G. J. Sui, Y. H. Liu, J. Gosney, E. Harris, I. S. Anand

Medicine - Veteran's Administration Medical Center

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Abstract

A male infant of 16 months, of the Han race, died from subacute infantile mountain sickness in Lhasa (3600 m). At necropsy there was right ventricular hypertrophy secondary to muscularization of the pulmonary arteries and arterioles thought to have been induced by hypobaric hypoxia. In addition, there was intimal proliferation of myofibroblasts in the pulmonary arterioles, venules and veins. There were increased numbers within the bronchioles of pulmonary endocrine cells, containing calcitonin and bombesin, which could be related to hypoxia or trophic effects on the pulmonary vasculature. The relation of delayed effects of hypoxia to primary pulmonary hypertension is considered in this study.

Original language	English (US)
Pages (from-to)	77-81
Number of pages	5
Journal	Respiratory Medicine
Volume	83
Issue number	1
DOIs	https://doi.org/10.1016/S0954-6111(89)80064-2
State	Published - 1989

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abstract = "A male infant of 16 months, of the Han race, died from subacute infantile mountain sickness in Lhasa (3600 m). At necropsy there was right ventricular hypertrophy secondary to muscularization of the pulmonary arteries and arterioles thought to have been induced by hypobaric hypoxia. In addition, there was intimal proliferation of myofibroblasts in the pulmonary arterioles, venules and veins. There were increased numbers within the bronchioles of pulmonary endocrine cells, containing calcitonin and bombesin, which could be related to hypoxia or trophic effects on the pulmonary vasculature. The relation of delayed effects of hypoxia to primary pulmonary hypertension is considered in this study.",

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T1 - Pulmonary blood vessels and endocrine cells in subacute infantile mountain sickness

AU - Heath, D.

AU - Harris, P.

AU - Sui, G. J.

AU - Liu, Y. H.

AU - Gosney, J.

AU - Harris, E.

AU - Anand, I. S.

PY - 1989

Y1 - 1989

N2 - A male infant of 16 months, of the Han race, died from subacute infantile mountain sickness in Lhasa (3600 m). At necropsy there was right ventricular hypertrophy secondary to muscularization of the pulmonary arteries and arterioles thought to have been induced by hypobaric hypoxia. In addition, there was intimal proliferation of myofibroblasts in the pulmonary arterioles, venules and veins. There were increased numbers within the bronchioles of pulmonary endocrine cells, containing calcitonin and bombesin, which could be related to hypoxia or trophic effects on the pulmonary vasculature. The relation of delayed effects of hypoxia to primary pulmonary hypertension is considered in this study.

AB - A male infant of 16 months, of the Han race, died from subacute infantile mountain sickness in Lhasa (3600 m). At necropsy there was right ventricular hypertrophy secondary to muscularization of the pulmonary arteries and arterioles thought to have been induced by hypobaric hypoxia. In addition, there was intimal proliferation of myofibroblasts in the pulmonary arterioles, venules and veins. There were increased numbers within the bronchioles of pulmonary endocrine cells, containing calcitonin and bombesin, which could be related to hypoxia or trophic effects on the pulmonary vasculature. The relation of delayed effects of hypoxia to primary pulmonary hypertension is considered in this study.

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Pulmonary blood vessels and endocrine cells in subacute infantile mountain sickness

Abstract

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