TY - JOUR
T1 - Pulmonary Blastomycosis in Children
T2 - Amphotericin B Therapy and a Review
AU - Chesney, Joan Cook
AU - Gourley, Glenn R.
AU - Peters, Mary Ellen
AU - Moffet, Hugh L.
PY - 1979/11
Y1 - 1979/11
N2 - Two children, aged 3 months and 4 years, respectively, were treated with ten weeks of amphotericin B for culture proved pulmonary blastomycosis. Organisms were easily demonstrated in nasopharyngeal or sputum specimens on admission. Although organisms were present until the 12th and 19th days of therapy, respectively, they were viable through only the seventh and 12th days of therapy. Both patients had thrombophlebitis, anemia, neutropenia, hypokalemia, fever, and vomiting develop during therapy. The less toxic drug hydroxystilbamidine isethionate, given for only 17 to 30 days, has been used successfully in at least six previously reported cases. Long courses of amphotericin B therapy may not be necessary for the treatment of pulmonary blastomycosis in selected children.
AB - Two children, aged 3 months and 4 years, respectively, were treated with ten weeks of amphotericin B for culture proved pulmonary blastomycosis. Organisms were easily demonstrated in nasopharyngeal or sputum specimens on admission. Although organisms were present until the 12th and 19th days of therapy, respectively, they were viable through only the seventh and 12th days of therapy. Both patients had thrombophlebitis, anemia, neutropenia, hypokalemia, fever, and vomiting develop during therapy. The less toxic drug hydroxystilbamidine isethionate, given for only 17 to 30 days, has been used successfully in at least six previously reported cases. Long courses of amphotericin B therapy may not be necessary for the treatment of pulmonary blastomycosis in selected children.
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U2 - 10.1001/archpedi.1979.02130110042005
DO - 10.1001/archpedi.1979.02130110042005
M3 - Article
C2 - 583093
AN - SCOPUS:0018611554
VL - 133
SP - 1134
EP - 1139
JO - A.M.A. American journal of diseases of children
JF - A.M.A. American journal of diseases of children
SN - 2168-6203
IS - 11
ER -