Public human microbiome data are dominated by highly developed countries

Richard J Abdill, Elizabeth M. Adamowicz, Ran Blekhman

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

The:importance of sampling from globally representative populations : has been well established in human genomics. In human microbiome research, however, we lack a full understanding of the global distribution of sampling in research studies. This information is crucial to better understand global patterns of microbiome-associated diseases and to extend the health benefits of this research to all populations. Here, we analyze the country of origin of all 444,829 human microbiome samples that are available from the world’s 3 largest genomic data repositories, including the Sequence Read Archive (SRA). The samples are from 2,592 studies of 19 body sites, including 220,017 samples of the gut microbiome. We show that more than 71% of samples with a known origin come from Europe, the United States, and Canada, including 46.8% from the US alone, despite the country representing only 4.3% of the global population. We also find that central and southern Asia is the most underrepresented region: Countries such as India, Pakistan, and Bangladesh account for more than a quarter of the world population but make up only 1.8% of human microbiome samples. These results demonstrate a critical need to ensure more global representation of participants in microbiome studies.

Original languageEnglish (US)
Article numbere3001536
JournalPLoS biology
Volume20
Issue number2
DOIs
StatePublished - Feb 2022

Bibliographical note

Funding Information:
This work was supported by the National Institute of General Medical Sciences of the National Institutes of Health (R35GM128716 to RB; https://www.nigms.nih.gov). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Publisher Copyright:
© 2022 Abdill et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural

Fingerprint

Dive into the research topics of 'Public human microbiome data are dominated by highly developed countries'. Together they form a unique fingerprint.

Cite this