Psychometric deviance in offspring at risk for schizophrenia: I. Initial delineation of a distinct subgroup

Steven O. Moldin; Irving I. Gottesman; L. Erlenmeyer-Kimling; Barbara A. Cornblatt

doi:10.1016/0165-1781(90)90035-4

Psychometric deviance in offspring at risk for schizophrenia: I. Initial delineation of a distinct subgroup

Steven O. Moldin
, Irving I. Gottesman
, L. Erlenmeyer-Kimling
, Barbara A. Cornblatt

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Psychometric signs from the Minnesota Multiphasic Personality Inventory (MMPI), which measure substantive disturbances in thinking, social relatedness, volition, and affective expressivity, were evaluated as possible indicators of transmissible liability specific to schizophrenia. Children of three criterion groups in the New York High-Risk Project-offspring at high risk (HR) for schizophrenia, psychiatric comparison (PC) offspring at risk for affective disorders, and normal comparison (NC) offspring not at augmented risk for psychiatric morbidity-were tested before the expression of schizophrenic psychopathology, when the subjects ranged in age from 13 to 26 years. The rate of psychometric deviance in the HR group (23%) was significantly higher than that in either the PC (7%) or NC (2%) groups, and profile analyses showed that the HR subgroup could be delineated by qualitative distinctions in personality functioning. Our results support the utility of MMPI indicators in etiologic investigations of schizophrenia.

Original language	English (US)
Pages (from-to)	297-310
Number of pages	14
Journal	Psychiatry Research
Volume	32
Issue number	3
DOIs	https://doi.org/10.1016/0165-1781(90)90035-4
State	Published - Jun 1990
Externally published	Yes

Bibliographical note

Funding Information:
Acknowledgment. This research was supported in part by a Dissertation Research Fellowship from the Scottish Rite Schizophrenia Research Program, Northern Masonic Jurisdiction, and by NIMH Research Training Grant MH-14677 to Dr. Moldin, NIMH grant MH-19560 to Dr. Erlenmeyer-Kimling, a fellowship from the Center for AdvancedS tudiesi n the Behavioral Sciences to Dr. Gottesman, the John D. and Catherine T. MacArthur Foundation, Clinical Research Center NIMH Grant MH-30906 to the Psychiatric Institute’s Computer Center, and the Department of Mental Hygiene of the State of New York. Simone Roberts and Marietta Bell aided in data analysis; Ulla Hilldoff Adamo catalogued MMPI protocols; Dr. Harold Gilberstadt (retired), formerly at the MMPI Research Laboratory of the Minneapolis VA Hospital, scored the MMPI; Drs. Joseph Fleiss and John P. Rice, along with Jing Shur, gave statistical advice; Drs. Robert Dworkin, Neil Skolnick, and Allan Goldstein commented constructively on an earlier version of this article.

Keywords

Minnesota Multiphasic Personality Inventory
Schizophrenia
genetics
high-risk studies
indicators of liability
profile analysis

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10.1016/0165-1781(90)90035-4

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title = "Psychometric deviance in offspring at risk for schizophrenia: I. Initial delineation of a distinct subgroup",

abstract = "Psychometric signs from the Minnesota Multiphasic Personality Inventory (MMPI), which measure substantive disturbances in thinking, social relatedness, volition, and affective expressivity, were evaluated as possible indicators of transmissible liability specific to schizophrenia. Children of three criterion groups in the New York High-Risk Project-offspring at high risk (HR) for schizophrenia, psychiatric comparison (PC) offspring at risk for affective disorders, and normal comparison (NC) offspring not at augmented risk for psychiatric morbidity-were tested before the expression of schizophrenic psychopathology, when the subjects ranged in age from 13 to 26 years. The rate of psychometric deviance in the HR group (23\%) was significantly higher than that in either the PC (7\%) or NC (2\%) groups, and profile analyses showed that the HR subgroup could be delineated by qualitative distinctions in personality functioning. Our results support the utility of MMPI indicators in etiologic investigations of schizophrenia.",

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author = "Moldin, \{Steven O.\} and Gottesman, \{Irving I.\} and L. Erlenmeyer-Kimling and Cornblatt, \{Barbara A.\}",

note = "Funding Information: Acknowledgment. This research was supported in part by a Dissertation Research Fellowship from the Scottish Rite Schizophrenia Research Program, Northern Masonic Jurisdiction, and by NIMH Research Training Grant MH-14677 to Dr. Moldin, NIMH grant MH-19560 to Dr. Erlenmeyer-Kimling, a fellowship from the Center for AdvancedS tudiesi n the Behavioral Sciences to Dr. Gottesman, the John D. and Catherine T. MacArthur Foundation, Clinical Research Center NIMH Grant MH-30906 to the Psychiatric Institute{\textquoteright}s Computer Center, and the Department of Mental Hygiene of the State of New York. Simone Roberts and Marietta Bell aided in data analysis; Ulla Hilldoff Adamo catalogued MMPI protocols; Dr. Harold Gilberstadt (retired), formerly at the MMPI Research Laboratory of the Minneapolis VA Hospital, scored the MMPI; Drs. Joseph Fleiss and John P. Rice, along with Jing Shur, gave statistical advice; Drs. Robert Dworkin, Neil Skolnick, and Allan Goldstein commented constructively on an earlier version of this article.",

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doi = "10.1016/0165-1781(90)90035-4",

language = "English (US)",

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AU - Cornblatt, Barbara A.

N1 - Funding Information: Acknowledgment. This research was supported in part by a Dissertation Research Fellowship from the Scottish Rite Schizophrenia Research Program, Northern Masonic Jurisdiction, and by NIMH Research Training Grant MH-14677 to Dr. Moldin, NIMH grant MH-19560 to Dr. Erlenmeyer-Kimling, a fellowship from the Center for AdvancedS tudiesi n the Behavioral Sciences to Dr. Gottesman, the John D. and Catherine T. MacArthur Foundation, Clinical Research Center NIMH Grant MH-30906 to the Psychiatric Institute’s Computer Center, and the Department of Mental Hygiene of the State of New York. Simone Roberts and Marietta Bell aided in data analysis; Ulla Hilldoff Adamo catalogued MMPI protocols; Dr. Harold Gilberstadt (retired), formerly at the MMPI Research Laboratory of the Minneapolis VA Hospital, scored the MMPI; Drs. Joseph Fleiss and John P. Rice, along with Jing Shur, gave statistical advice; Drs. Robert Dworkin, Neil Skolnick, and Allan Goldstein commented constructively on an earlier version of this article.

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N2 - Psychometric signs from the Minnesota Multiphasic Personality Inventory (MMPI), which measure substantive disturbances in thinking, social relatedness, volition, and affective expressivity, were evaluated as possible indicators of transmissible liability specific to schizophrenia. Children of three criterion groups in the New York High-Risk Project-offspring at high risk (HR) for schizophrenia, psychiatric comparison (PC) offspring at risk for affective disorders, and normal comparison (NC) offspring not at augmented risk for psychiatric morbidity-were tested before the expression of schizophrenic psychopathology, when the subjects ranged in age from 13 to 26 years. The rate of psychometric deviance in the HR group (23%) was significantly higher than that in either the PC (7%) or NC (2%) groups, and profile analyses showed that the HR subgroup could be delineated by qualitative distinctions in personality functioning. Our results support the utility of MMPI indicators in etiologic investigations of schizophrenia.

AB - Psychometric signs from the Minnesota Multiphasic Personality Inventory (MMPI), which measure substantive disturbances in thinking, social relatedness, volition, and affective expressivity, were evaluated as possible indicators of transmissible liability specific to schizophrenia. Children of three criterion groups in the New York High-Risk Project-offspring at high risk (HR) for schizophrenia, psychiatric comparison (PC) offspring at risk for affective disorders, and normal comparison (NC) offspring not at augmented risk for psychiatric morbidity-were tested before the expression of schizophrenic psychopathology, when the subjects ranged in age from 13 to 26 years. The rate of psychometric deviance in the HR group (23%) was significantly higher than that in either the PC (7%) or NC (2%) groups, and profile analyses showed that the HR subgroup could be delineated by qualitative distinctions in personality functioning. Our results support the utility of MMPI indicators in etiologic investigations of schizophrenia.

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Psychometric deviance in offspring at risk for schizophrenia: I. Initial delineation of a distinct subgroup

Abstract

Bibliographical note

Keywords

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