Psychometric deviance in offspring at risk for schizophrenia: I. Initial delineation of a distinct subgroup

Steven O. Moldin, Irving I. Gottesman, L. Erlenmeyer-Kimling, Barbara A. Cornblatt

Research output: Contribution to journalArticle

35 Scopus citations


Psychometric signs from the Minnesota Multiphasic Personality Inventory (MMPI), which measure substantive disturbances in thinking, social relatedness, volition, and affective expressivity, were evaluated as possible indicators of transmissible liability specific to schizophrenia. Children of three criterion groups in the New York High-Risk Project-offspring at high risk (HR) for schizophrenia, psychiatric comparison (PC) offspring at risk for affective disorders, and normal comparison (NC) offspring not at augmented risk for psychiatric morbidity-were tested before the expression of schizophrenic psychopathology, when the subjects ranged in age from 13 to 26 years. The rate of psychometric deviance in the HR group (23%) was significantly higher than that in either the PC (7%) or NC (2%) groups, and profile analyses showed that the HR subgroup could be delineated by qualitative distinctions in personality functioning. Our results support the utility of MMPI indicators in etiologic investigations of schizophrenia.

Original languageEnglish (US)
Pages (from-to)297-310
Number of pages14
JournalPsychiatry Research
Issue number3
StatePublished - Jun 1990


  • Minnesota Multiphasic Personality Inventory
  • Schizophrenia
  • genetics
  • high-risk studies
  • indicators of liability
  • profile analysis

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