Psycho-social predictors of chronicity in depressed patients

R. M.A. Hirschfeld, G. L. Klerman, N. C. Andreasen, P. J. Clayton, M. B. Keller

Research output: Contribution to journalArticlepeer-review

141 Scopus citations


Nineteen patients with an episode of major depressive disorder who did not recover within two years of prospective follow-up were compared with an equal number who recovered within a year of the initial evaluation and remained well through the two-year follow-up date. The groups were individually matched for age, sex, primary/secondary status, and prior duration of episode. The only psycho-social variable that predicted chronicity was increased neuroticism on self-report personality inventories administered during the index evaluation. Early loss, recent life events, and recent social supports were not predictive of outcome.

Original languageEnglish (US)
Pages (from-to)648-654
Number of pages7
JournalBritish Journal of Psychiatry
Issue numberJUNE
StatePublished - 1986


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