Abstract
Enzyme protection: An irreversible solid-phase, aqueous peptide coupling resulted in the formation of a library of eight dipeptides, while an irreversible protease-catalyzed hydrolysis destroyed them. Those dipeptides that bound to carbonic anhydrase were protected from destructions. Six cycles of active ester addition produced only the best-binding dipeptide (> 100:1) in 29% yield.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2432-2436 |
| Number of pages | 5 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 43 |
| Issue number | 18 |
| DOIs | |
| State | Published - Apr 26 2004 |
Keywords
- Combinatorial chemistry
- Drug design
- Enzyme inhibitors
- Kinetics
- Receptors
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