Proton T2 relaxation study of water, N-acetylaspartate, and creatine in human brain using Hahn and Carr-Purcell spin echoes at 4T and 7T

Shalom Michaeli; Michael Garwood; Xiao-Hong Zhu; Lance DelaBarre; Peter M Andersen; Gregor Adriany; Hellmut Merkle; Kamil Ugurbil; Wei Chen

doi:10.1002/mrm.10135

Proton T₂ relaxation study of water, N-acetylaspartate, and creatine in human brain using Hahn and Carr-Purcell spin echoes at 4T and 7T

Shalom Michaeli, Michael Garwood, Xiao-Hong Zhu, Lance DelaBarre, Peter M Andersen, Gregor Adriany, Hellmut Merkle, Kamil Ugurbil, Wei Chen

Research output: Contribution to journal › Article › peer-review

183 Scopus citations

Abstract

Carr-Purcell and Hahn spin-echo (SE) measurements were used to estimate the apparent transverse relaxation time constant (T₂⁺) of water and metabolites in human brain at 4T and 7T. A significant reduction in the T₂⁺ values of proton resonances (water, N-acetylaspartate, and creatine/phosphocreatine) was observed with increasing magnetic field strength and was attributed mainly to increased dynamic dephasing due to increased local susceptibility gradients. At high field, signal loss resulting from T₂⁺ decay can be substantially reduced using a Carr-Purcell-type SE sequence.

Original language	English (US)
Pages (from-to)	629-633
Number of pages	5
Journal	Magnetic resonance in medicine
Volume	47
Issue number	4
DOIs	https://doi.org/10.1002/mrm.10135
State	Published - 2002

Keywords

Adiabatic pulse
Carr-Purcell spin echo
Cerebral metabolites
High magnetic field
T relaxation time

Publisher link

10.1002/mrm.10135

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title = "Proton T2 relaxation study of water, N-acetylaspartate, and creatine in human brain using Hahn and Carr-Purcell spin echoes at 4T and 7T",

abstract = "Carr-Purcell and Hahn spin-echo (SE) measurements were used to estimate the apparent transverse relaxation time constant (T2+) of water and metabolites in human brain at 4T and 7T. A significant reduction in the T2+ values of proton resonances (water, N-acetylaspartate, and creatine/phosphocreatine) was observed with increasing magnetic field strength and was attributed mainly to increased dynamic dephasing due to increased local susceptibility gradients. At high field, signal loss resulting from T2+ decay can be substantially reduced using a Carr-Purcell-type SE sequence.",

keywords = "Adiabatic pulse, Carr-Purcell spin echo, Cerebral metabolites, High magnetic field, T relaxation time",

author = "Shalom Michaeli and Michael Garwood and Xiao-Hong Zhu and Lance DelaBarre and Andersen, \{Peter M\} and Gregor Adriany and Hellmut Merkle and Kamil Ugurbil and Wei Chen",

year = "2002",

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language = "English (US)",

volume = "47",

pages = "629--633",

journal = "Magnetic resonance in medicine",

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TY - JOUR

T1 - Proton T2 relaxation study of water, N-acetylaspartate, and creatine in human brain using Hahn and Carr-Purcell spin echoes at 4T and 7T

AU - Michaeli, Shalom

AU - Garwood, Michael

AU - Zhu, Xiao-Hong

AU - DelaBarre, Lance

AU - Andersen, Peter M

AU - Adriany, Gregor

AU - Merkle, Hellmut

AU - Ugurbil, Kamil

AU - Chen, Wei

PY - 2002

Y1 - 2002

N2 - Carr-Purcell and Hahn spin-echo (SE) measurements were used to estimate the apparent transverse relaxation time constant (T2+) of water and metabolites in human brain at 4T and 7T. A significant reduction in the T2+ values of proton resonances (water, N-acetylaspartate, and creatine/phosphocreatine) was observed with increasing magnetic field strength and was attributed mainly to increased dynamic dephasing due to increased local susceptibility gradients. At high field, signal loss resulting from T2+ decay can be substantially reduced using a Carr-Purcell-type SE sequence.

AB - Carr-Purcell and Hahn spin-echo (SE) measurements were used to estimate the apparent transverse relaxation time constant (T2+) of water and metabolites in human brain at 4T and 7T. A significant reduction in the T2+ values of proton resonances (water, N-acetylaspartate, and creatine/phosphocreatine) was observed with increasing magnetic field strength and was attributed mainly to increased dynamic dephasing due to increased local susceptibility gradients. At high field, signal loss resulting from T2+ decay can be substantially reduced using a Carr-Purcell-type SE sequence.

KW - Adiabatic pulse

KW - Carr-Purcell spin echo

KW - Cerebral metabolites

KW - High magnetic field

KW - T relaxation time

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U2 - 10.1002/mrm.10135

DO - 10.1002/mrm.10135

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SN - 0740-3194

VL - 47

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JO - Magnetic resonance in medicine

JF - Magnetic resonance in medicine

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