Proton T2 relaxation study of water, N-acetylaspartate, and creatine in human brain using Hahn and Carr-Purcell spin echoes at 4T and 7T

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Abstract

Carr-Purcell and Hahn spin-echo (SE) measurements were used to estimate the apparent transverse relaxation time constant (T2+) of water and metabolites in human brain at 4T and 7T. A significant reduction in the T2+ values of proton resonances (water, N-acetylaspartate, and creatine/phosphocreatine) was observed with increasing magnetic field strength and was attributed mainly to increased dynamic dephasing due to increased local susceptibility gradients. At high field, signal loss resulting from T2+ decay can be substantially reduced using a Carr-Purcell-type SE sequence.

Original languageEnglish (US)
Pages (from-to)629-633
Number of pages5
JournalMagnetic resonance in medicine
Volume47
Issue number4
DOIs
StatePublished - Apr 10 2002

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Keywords

  • Adiabatic pulse
  • Carr-Purcell spin echo
  • Cerebral metabolites
  • High magnetic field
  • T relaxation time

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