Proton magnetic resonance spectroscopy of a gray matter heterotopia

L. Marsh, K. O. Lim, E. V. Sullivan, B. Lane, D. Spielman

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


We used proton magnetic resonance spectroscopy to examine resonances representing metabolites containing N-acetyl (NA) groups (predominantly N- acetyl aspartate), choline, and creatine within a large left-hemispheric gray matter heterotopia (GMH) in a 35-year-old man with corpus callosum agenesis. In contrast to normal brain tissue, including gray matter regions, heterotopic gray matter was characterized by relatively increased choline and creatine resonances and a normal NA signal. These data suggest increased cellular activity or persistent immature neuronal tissue in GMH relative to unaffected tissue.

Original languageEnglish (US)
Pages (from-to)1571-1574
Number of pages4
Issue number6
StatePublished - Dec 1996


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