Proton magnetic resonance spectroscopic imaging of cortical gray and white matter in schizophrenia

Kelvin O. Lim, Elfar Adalstcinsson, Daniel Spielman, Edith V. Sullivan, Margaret J. Roscnbloom, Adolf Pfefferbaum

Research output: Contribution to journalArticlepeer-review

114 Scopus citations

Abstract

Objective: To apply in vivo proton magnetic resonance spectroscopy imaging estimates of N-acetylaspartate (NAA), a neuronal marker, to clarify the relative contribution of neuronal and glial changes to the widespread volume deficit of cortical gray matter seen in patients with schizophrenia with magnetic resonance images. Methods: Ten male veterans meeting criteria of the DSM-IV, for schizophrenia and 9 healthy age-matched men for comparison were scanned using spectroscopic, anatomical, and field-map sequences. Instrument and collection variables were standardized to allow an estimation of comparable values of NAA, choline, and creatine for all subjects. Metabolite values from each voxel on 3 upper cortical slices were regressed against the gray tissue proportion of that voxel to derive estimates of gray and white matter NAA creatine, and choline concentrations. Results: The volume of cortical gray matter was reduced in patients with schizophrenia, but NAA signal intensity from a comparable region was normal. In contrast, the volume of cortical white matter was normal in patients with schizophrenia, but NAA signal intensity from a comparable region was reduced. Conclusions: The lack of reduction in gray matter NAA signal intensity suggests that the cortical gray matter deficit in these patients involve both neuronal and glial compartments rather than a neurodegenerative process in which there is a decrease in the neuronal relative to the glial compartment. Reduced white matter NAA signal intensity without a white matter volume deficit may reflect abnormal axonal connections.

Original languageEnglish (US)
Pages (from-to)346-352
Number of pages7
JournalArchives of General Psychiatry
Volume55
Issue number4
DOIs
StatePublished - 1998

Fingerprint Dive into the research topics of 'Proton magnetic resonance spectroscopic imaging of cortical gray and white matter in schizophrenia'. Together they form a unique fingerprint.

Cite this