Proteomic signature of HIV-associated subclinical left atrial remodeling and incident heart failure

Tess E Peterson; Virginia S Hahn; Ruin Moaddel; Min Zhu; Sabina A Haberlen; Frank J Palella; Michael Plankey; Joel S Bader; Joao A C Lima; Robert E Gerszten; Jerome I Rotter; Stephen S Rich; Susan R Heckbert; Gregory D Kirk; Damani A Piggott; Luigi Ferrucci; Joseph B Margolick; Todd T Brown; Katherine C Wu; Wendy S Post

doi:10.1038/s41467-025-55911-0

Proteomic signature of HIV-associated subclinical left atrial remodeling and incident heart failure

Tess E Peterson
, Virginia S Hahn
, Ruin Moaddel
, Min Zhu
, Sabina A Haberlen
, Frank J Palella
, Michael Plankey
, Joel S Bader
, Joao A C Lima
, Robert E Gerszten
, Jerome I Rotter
, Stephen S Rich
, Susan R Heckbert
, Gregory D Kirk
, Damani A Piggott
, Luigi Ferrucci
, Joseph B Margolick
, Todd T Brown
, Katherine C Wu
, Wendy S Post

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

People living with HIV are at higher risk of heart failure and associated left atrial remodeling compared to people without HIV. Mechanisms are unclear but have been linked to inflammation and premature aging. Here we obtain plasma proteomics concurrently with cardiac magnetic resonance imaging in two independent study populations to identify parallels between HIV-related and aging-related immune dysfunction that could contribute to atrial remodeling and clinical heart failure. We discover a plasma proteomic signature that may in part reflect or contribute to HIV-associated atrial remodeling, many features of which are associated with older age and time to incident heart failure among an independent community-based cohort without HIV. This proteomic profile was statistically enriched for immune checkpoint proteins, tumor necrosis factor signaling, ephrin signaling, and extracellular matrix organization, identifying possible shared pathways in HIV and aging that may contribute to risk of heart failure.

Original language	English (US)
Article number	610
Pages (from-to)	610
Number of pages	1
Journal	Nature communications
Volume	16
Issue number	1
DOIs	https://doi.org/10.1038/s41467-025-55911-0
State	Published - Dec 2025

Bibliographical note

Publisher Copyright:
© The Author(s) 2025.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Humans
Heart Failure/blood
HIV Infections/blood
Proteomics/methods
Female
Male
Middle Aged
Atrial Remodeling
Adult
Magnetic Resonance Imaging
Heart Atria/diagnostic imaging
Proteome/metabolism

PubMed: MeSH publication types

Journal Article

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10.1038/s41467-025-55911-0License: CC BY-NC-ND

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Peterson, T. E., Hahn, V. S., Moaddel, R., Zhu, M., Haberlen, S. A., Palella, F. J., Plankey, M., Bader, J. S., Lima, J. A. C., Gerszten, R. E., Rotter, J. I., Rich, S. S., Heckbert, S. R., Kirk, G. D., Piggott, D. A., Ferrucci, L., Margolick, J. B., Brown, T. T., Wu, K. C., & Post, W. S. (2025). Proteomic signature of HIV-associated subclinical left atrial remodeling and incident heart failure. Nature communications, 16(1), 610. Article 610. https://doi.org/10.1038/s41467-025-55911-0

Peterson, TE, Hahn, VS, Moaddel, R, Zhu, M, Haberlen, SA, Palella, FJ, Plankey, M, Bader, JS, Lima, JAC, Gerszten, RE, Rotter, JI, Rich, SS, Heckbert, SR, Kirk, GD, Piggott, DA, Ferrucci, L, Margolick, JB, Brown, TT, Wu, KC & Post, WS 2025, 'Proteomic signature of HIV-associated subclinical left atrial remodeling and incident heart failure', Nature communications, vol. 16, no. 1, 610, pp. 610. https://doi.org/10.1038/s41467-025-55911-0

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abstract = "People living with HIV are at higher risk of heart failure and associated left atrial remodeling compared to people without HIV. Mechanisms are unclear but have been linked to inflammation and premature aging. Here we obtain plasma proteomics concurrently with cardiac magnetic resonance imaging in two independent study populations to identify parallels between HIV-related and aging-related immune dysfunction that could contribute to atrial remodeling and clinical heart failure. We discover a plasma proteomic signature that may in part reflect or contribute to HIV-associated atrial remodeling, many features of which are associated with older age and time to incident heart failure among an independent community-based cohort without HIV. This proteomic profile was statistically enriched for immune checkpoint proteins, tumor necrosis factor signaling, ephrin signaling, and extracellular matrix organization, identifying possible shared pathways in HIV and aging that may contribute to risk of heart failure.",

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month = dec,

doi = "10.1038/s41467-025-55911-0",

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AU - Peterson, Tess E

AU - Hahn, Virginia S

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AU - Zhu, Min

AU - Haberlen, Sabina A

AU - Palella, Frank J

AU - Plankey, Michael

AU - Bader, Joel S

AU - Lima, Joao A C

AU - Gerszten, Robert E

AU - Rotter, Jerome I

AU - Rich, Stephen S

AU - Heckbert, Susan R

AU - Kirk, Gregory D

AU - Piggott, Damani A

AU - Ferrucci, Luigi

AU - Margolick, Joseph B

AU - Brown, Todd T

AU - Wu, Katherine C

AU - Post, Wendy S

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N2 - People living with HIV are at higher risk of heart failure and associated left atrial remodeling compared to people without HIV. Mechanisms are unclear but have been linked to inflammation and premature aging. Here we obtain plasma proteomics concurrently with cardiac magnetic resonance imaging in two independent study populations to identify parallels between HIV-related and aging-related immune dysfunction that could contribute to atrial remodeling and clinical heart failure. We discover a plasma proteomic signature that may in part reflect or contribute to HIV-associated atrial remodeling, many features of which are associated with older age and time to incident heart failure among an independent community-based cohort without HIV. This proteomic profile was statistically enriched for immune checkpoint proteins, tumor necrosis factor signaling, ephrin signaling, and extracellular matrix organization, identifying possible shared pathways in HIV and aging that may contribute to risk of heart failure.

AB - People living with HIV are at higher risk of heart failure and associated left atrial remodeling compared to people without HIV. Mechanisms are unclear but have been linked to inflammation and premature aging. Here we obtain plasma proteomics concurrently with cardiac magnetic resonance imaging in two independent study populations to identify parallels between HIV-related and aging-related immune dysfunction that could contribute to atrial remodeling and clinical heart failure. We discover a plasma proteomic signature that may in part reflect or contribute to HIV-associated atrial remodeling, many features of which are associated with older age and time to incident heart failure among an independent community-based cohort without HIV. This proteomic profile was statistically enriched for immune checkpoint proteins, tumor necrosis factor signaling, ephrin signaling, and extracellular matrix organization, identifying possible shared pathways in HIV and aging that may contribute to risk of heart failure.

KW - Humans

KW - Heart Failure/blood

KW - HIV Infections/blood

KW - Proteomics/methods

KW - Female

KW - Male

KW - Middle Aged

KW - Atrial Remodeling

KW - Adult

KW - Magnetic Resonance Imaging

KW - Heart Atria/diagnostic imaging

KW - Proteome/metabolism

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ER -

Proteomic signature of HIV-associated subclinical left atrial remodeling and incident heart failure

Abstract

Bibliographical note

UN SDGs

Keywords

PubMed: MeSH publication types

Publisher link

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