Proteomic Profile of the ICAM1 p.K56M HFpEF Risk Variant

Pedro Giro; Mallory Filipp; Michael J. Zhang; Ethan D. Moser; Edward B. Thorp; Prarthana J. Dalal; Ravi V. Shah; Patrick T. Ellinor; Jonathan W. Cunningham; Sean J. Jurgens; Arjun Sinha; Laura Rasmussen-Torvik; Jorge Kizer; Kent D. Taylor; Philip Greenland; Bruce M. Psaty; Russell P. Tracy; Lin Yee Chen; Amil M. Shah; Bing Yu; Sanjiv J. Shah; Ravi B. Patel

doi:10.1016/j.jacbts.2024.05.016

Proteomic Profile of the ICAM1 p.K56M HFpEF Risk Variant

Pedro Giro
, Mallory Filipp
, Michael J. Zhang
, Ethan D. Moser
, Edward B. Thorp
, Prarthana J. Dalal
, Ravi V. Shah
, Patrick T. Ellinor
, Jonathan W. Cunningham
, Sean J. Jurgens
, Arjun Sinha
, Laura Rasmussen-Torvik
, Jorge Kizer
, Kent D. Taylor
, Philip Greenland
, Bruce M. Psaty
, Russell P. Tracy
, Lin Yee Chen
, Amil M. Shah
, Bing Yu

Sanjiv J. Shah, Ravi B. Patel

Medicine - Cardiology Division

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

A common missense variant in ICAM1 among African American individuals (rs5491; pK56M) has been associated with risk of heart failure with preserved ejection fraction (HFpEF), but the pathways that lead to HFpEF among those with this variant are not clear. In this analysis of 92 circulating proteins and their associated networks, we identified 7 circulating inflammatory proteins associated with rs5491 among >600 African American individuals. Using weighted coexpression network analysis, 3 protein networks were identified, one of which was associated with rs5491. This protein network was most highly represented by members of the tumor necrosis receptor superfamily. The rs5491 variant demonstrated an inflammatory proteomic profile in a separate cohort of African American individuals. This analysis identifies inflammatory pathways that may drive HFpEF among African American individuals with the ICAM1 pK56M (rs5491) variant.

Original language	English (US)
Pages (from-to)	1073-1084
Number of pages	12
Journal	JACC: Basic to Translational Science
Volume	9
Issue number	9
DOIs	https://doi.org/10.1016/j.jacbts.2024.05.016
State	Published - Sep 2024

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Publisher Copyright:
© 2024 The Authors

Keywords

heart failure with preserved ejection fraction
intercellular adhesion molecule-1
proteomics
rs5491

PubMed: MeSH publication types

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Giro, P., Filipp, M., Zhang, M. J., Moser, E. D., Thorp, E. B., Dalal, P. J., Shah, R. V., Ellinor, P. T., Cunningham, J. W., Jurgens, S. J., Sinha, A., Rasmussen-Torvik, L., Kizer, J., Taylor, K. D., Greenland, P., Psaty, B. M., Tracy, R. P., Chen, L. Y., Shah, A. M., ... Patel, R. B. (2024). Proteomic Profile of the ICAM1 p.K56M HFpEF Risk Variant. JACC: Basic to Translational Science, 9(9), 1073-1084. https://doi.org/10.1016/j.jacbts.2024.05.016

Giro, P, Filipp, M, Zhang, MJ, Moser, ED, Thorp, EB, Dalal, PJ, Shah, RV, Ellinor, PT, Cunningham, JW, Jurgens, SJ, Sinha, A, Rasmussen-Torvik, L, Kizer, J, Taylor, KD, Greenland, P, Psaty, BM, Tracy, RP, Chen, LY, Shah, AM, Yu, B, Shah, SJ & Patel, RB 2024, 'Proteomic Profile of the ICAM1 p.K56M HFpEF Risk Variant', JACC: Basic to Translational Science, vol. 9, no. 9, pp. 1073-1084. https://doi.org/10.1016/j.jacbts.2024.05.016

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title = "Proteomic Profile of the ICAM1 p.K56M HFpEF Risk Variant",

abstract = "A common missense variant in ICAM1 among African American individuals (rs5491; pK56M) has been associated with risk of heart failure with preserved ejection fraction (HFpEF), but the pathways that lead to HFpEF among those with this variant are not clear. In this analysis of 92 circulating proteins and their associated networks, we identified 7 circulating inflammatory proteins associated with rs5491 among >600 African American individuals. Using weighted coexpression network analysis, 3 protein networks were identified, one of which was associated with rs5491. This protein network was most highly represented by members of the tumor necrosis receptor superfamily. The rs5491 variant demonstrated an inflammatory proteomic profile in a separate cohort of African American individuals. This analysis identifies inflammatory pathways that may drive HFpEF among African American individuals with the ICAM1 pK56M (rs5491) variant.",

keywords = "heart failure with preserved ejection fraction, intercellular adhesion molecule-1, proteomics, rs5491",

author = "Pedro Giro and Mallory Filipp and Zhang, \{Michael J.\} and Moser, \{Ethan D.\} and Thorp, \{Edward B.\} and Dalal, \{Prarthana J.\} and Shah, \{Ravi V.\} and Ellinor, \{Patrick T.\} and Cunningham, \{Jonathan W.\} and Jurgens, \{Sean J.\} and Arjun Sinha and Laura Rasmussen-Torvik and Jorge Kizer and Taylor, \{Kent D.\} and Philip Greenland and Psaty, \{Bruce M.\} and Tracy, \{Russell P.\} and Chen, \{Lin Yee\} and Shah, \{Amil M.\} and Bing Yu and Shah, \{Sanjiv J.\} and Patel, \{Ravi B.\}",

note = "Publisher Copyright: {\textcopyright} 2024 The Authors",

year = "2024",

month = sep,

doi = "10.1016/j.jacbts.2024.05.016",

language = "English (US)",

volume = "9",

pages = "1073--1084",

journal = "JACC: Basic to Translational Science",

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AU - Filipp, Mallory

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AU - Moser, Ethan D.

AU - Thorp, Edward B.

AU - Dalal, Prarthana J.

AU - Shah, Ravi V.

AU - Ellinor, Patrick T.

AU - Cunningham, Jonathan W.

AU - Jurgens, Sean J.

AU - Sinha, Arjun

AU - Rasmussen-Torvik, Laura

AU - Kizer, Jorge

AU - Taylor, Kent D.

AU - Greenland, Philip

AU - Psaty, Bruce M.

AU - Tracy, Russell P.

AU - Chen, Lin Yee

AU - Shah, Amil M.

AU - Yu, Bing

AU - Shah, Sanjiv J.

AU - Patel, Ravi B.

PY - 2024/9

Y1 - 2024/9

N2 - A common missense variant in ICAM1 among African American individuals (rs5491; pK56M) has been associated with risk of heart failure with preserved ejection fraction (HFpEF), but the pathways that lead to HFpEF among those with this variant are not clear. In this analysis of 92 circulating proteins and their associated networks, we identified 7 circulating inflammatory proteins associated with rs5491 among >600 African American individuals. Using weighted coexpression network analysis, 3 protein networks were identified, one of which was associated with rs5491. This protein network was most highly represented by members of the tumor necrosis receptor superfamily. The rs5491 variant demonstrated an inflammatory proteomic profile in a separate cohort of African American individuals. This analysis identifies inflammatory pathways that may drive HFpEF among African American individuals with the ICAM1 pK56M (rs5491) variant.

AB - A common missense variant in ICAM1 among African American individuals (rs5491; pK56M) has been associated with risk of heart failure with preserved ejection fraction (HFpEF), but the pathways that lead to HFpEF among those with this variant are not clear. In this analysis of 92 circulating proteins and their associated networks, we identified 7 circulating inflammatory proteins associated with rs5491 among >600 African American individuals. Using weighted coexpression network analysis, 3 protein networks were identified, one of which was associated with rs5491. This protein network was most highly represented by members of the tumor necrosis receptor superfamily. The rs5491 variant demonstrated an inflammatory proteomic profile in a separate cohort of African American individuals. This analysis identifies inflammatory pathways that may drive HFpEF among African American individuals with the ICAM1 pK56M (rs5491) variant.

KW - heart failure with preserved ejection fraction

KW - intercellular adhesion molecule-1

KW - proteomics

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Proteomic Profile of the ICAM1 p.K56M HFpEF Risk Variant

Abstract

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Keywords

PubMed: MeSH publication types

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