Proteinuria and lipoprotein lipase activity in Miniature Schnauzer dogs with and without hypertriglyceridemia

E. Furrow, J. Q. Jaeger, V. J. Parker, K. W. Hinchcliff, S. E. Johnson, S. J. Murdoch, I. H. de Boer, R. G. Sherding, J. D. Brunzell

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Spontaneous hyperlipidemia in rats causes glomerular disease. Idiopathic hypertriglyceridemia (HTG) is prevalent in Miniature Schnauzers, but its relationship with proteinuria is unknown. Decreased activity of major lipid metabolism enzymes, lipoprotein lipase (LPL) and hepatic lipase (HL), may play a role in the cyclic relationship between hyperlipidemia and proteinuria. These enzymes have also not been previously investigated in Miniature Schnauzers. The aims of this study were to determine the relationship between HTG and proteinuria in Miniature Schnauzers and to measure LPL and HL activities in a subset of dogs. Fifty-seven Miniature Schnauzers were recruited (34 with and 23 without HTG). Fasting serum triglyceride concentrations and urine protein-to-creatinine ratios (UPC) were measured in all dogs, and LPL and HL activities were determined in 17 dogs (8 with and 9 without HTG). There was a strong positive correlation between triglyceride concentration and UPC (r = 0.77–0.83, P < 0.001). Proteinuria (UPC ≥ 0.5) was present in 60% of dogs with HTG and absent from all dogs without HTG (P < 0.001). Proteinuric dogs were not azotemic or hypoalbuminemic. Dogs with HTG had a 65% reduction in LPL activity relative to dogs without HTG (P < 0.001); HL activity did not differ. Proteinuria occurs with HTG in Miniature Schnauzers and could be due to lipid-induced glomerular injury. Reduced LPL activity may contribute to the severity of HTG, but further assay validation is required.

Original languageEnglish (US)
Pages (from-to)83-89
Number of pages7
JournalVeterinary Journal
Volume212
DOIs
StatePublished - Jun 1 2016

Bibliographical note

Funding Information:
The research was funded by a donation from Mr and Mrs James and Virginia Squeo, the Ohio State University Canine Research Foundation Grant ( 2000-46 ) and a Morris Animal Foundation grant ( D12CA-031 ). Partial funding for Dr Furrow is provided by an NIH ORIP K01 Mentored Research Scientist Development Award ( K01OD019912 ). The authors thank Aaron Rendahl for statistical support, the Medical Records Department at The Ohio State University Veterinary Medical Center for maintaining and providing medical records, and the Center for Investigative Studies at the University of Minnesota Veterinary Medical Center for recruiting dogs and collecting samples for the study. Preliminary results of the study were presented as an abstract at the 2003 American College of Veterinary Internal Medicine (ACVIM) Forum in Charlotte, NC, USA, a scientific session at the 2013 ACVIM Forum in Seattle, WA, USA and a research report at the 2015 ACVIM Forum in Indianapolis, IN, USA. A subset of this work was a chapter in Dr Jaeger's thesis submitted to the Faculty of the Graduate School of the Ohio State University in partial fulfillment of the requirements for a Master of Science (MS) degree.

Publisher Copyright:
© 2016 Elsevier Ltd

Keywords

  • Canine
  • Glomerular disease
  • Hyperlipidemia
  • Miniature Schnauzer
  • Triglycerides

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