Protein-observed ¹⁹F-NMR for fragment screening, affinity quantification and druggability assessment

Keyphrases

• Screening Approach 100%
• 19F NMR 100%
• Fragment Screening 100%
• Druggability Evaluation 100%
• Quantification Assessment 100%
• Bromodomain 50%
• Protein Function 50%
• NMR Spectroscopy 50%
• Protein Targeting 50%
• Medium Size 50%
• Commercially Available 50%
• Selective Labeling 50%
• Small Molecule Ligands 50%
• Binding Affinity 50%
• Protein Folding 50%
• NMR Spectra 50%
• Druggability 50%
• Structural Information 50%
• Fluorinated 50%
• Bromodomain-containing Protein 4 (BRD4) 50%
• Aromatic Amino Acids 50%
• Multiple Proteins 50%
• CREB-binding Protein 50%
• Efficiency Calculation 50%
• KIX Domain 50%
• Brdt 50%
• Fluorinated Aromatics 50%
• Ligand Efficiency 50%
• Simple Spectrum 50%
• Labeled Amino Acid 50%

Chemistry

• 19F NMR Spectroscopy 100%
• NMR Spectroscopy 50%
• NMR Spectrum 50%
• Protein Folding 50%
• Kd 50%
• Aromatic Amino Acid 50%
• Amino Acid 50%
• Binding Protein 50%