Protein crystal growth in microgravity

L. J. DeLucas; C. D. Smith; H. W. Smith; S. Vijay-Kumar; S. E. Senadhi; S. E. Ealick; C. E. Bugg; D. C. Carter; R. S. Snyder; P. C. Weber; F. R. Salemme; D. H. Ohlendorf; H. M. Einspahr; L. L. Clancy; M. A. Navia; B. M. McKeever

Protein crystal growth in microgravity

L. J. DeLucas, C. D. Smith, H. W. Smith, S. Vijay-Kumar, S. E. Senadhi, S. E. Ealick, C. E. Bugg, D. C. Carter, R. S. Snyder, P. C. Weber, F. R. Salemme, D. H. Ohlendorf, H. M. Einspahr, L. L. Clancy, M. A. Navia, B. M. McKeever

Biochemistry, Molecular Biology, and Biophysics (TMED)

Research output: Contribution to journal › Conference article › peer-review

Abstract

Crystal growth has become a major bottleneck in further development of protein crystallography. One promising area of research is protein crystal growth in the microgravity environment of space. A series of growth experiments were performed on U.S. shuttle flight STS-26 in September, 1988 and STS-29 in March, 1989. For those proteins which produced crystals of adequate size, three-dimensional intensity data sets with electronic area detector systems were collected. Comparisons of the microgravity-grown crystals with the best earth-grown crystals demonstrate that the microgravity-grown crystals are larger, display more uniform morphologies, and yield diffraction data to significantly higher resolutions.

Original language	English (US)
Pages (from-to)	31-34
Number of pages	4
Journal	European Space Agency, (Special Publication) ESA SP
Issue number	295
State	Published - Dec 1 1989
Event	Proceedings of the 7th European Symposium on Materials and Fluid Sciences in Microgravity - Oxford, Engl Duration: Sep 10 1989 → Sep 15 1989

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@article{745f94e946f84865b80739c636d516b8,

title = "Protein crystal growth in microgravity",

abstract = "Crystal growth has become a major bottleneck in further development of protein crystallography. One promising area of research is protein crystal growth in the microgravity environment of space. A series of growth experiments were performed on U.S. shuttle flight STS-26 in September, 1988 and STS-29 in March, 1989. For those proteins which produced crystals of adequate size, three-dimensional intensity data sets with electronic area detector systems were collected. Comparisons of the microgravity-grown crystals with the best earth-grown crystals demonstrate that the microgravity-grown crystals are larger, display more uniform morphologies, and yield diffraction data to significantly higher resolutions.",

author = "DeLucas, {L. J.} and Smith, {C. D.} and Smith, {H. W.} and S. Vijay-Kumar and Senadhi, {S. E.} and Ealick, {S. E.} and Bugg, {C. E.} and Carter, {D. C.} and Snyder, {R. S.} and Weber, {P. C.} and Salemme, {F. R.} and Ohlendorf, {D. H.} and Einspahr, {H. M.} and Clancy, {L. L.} and Navia, {M. A.} and McKeever, {B. M.}",

year = "1989",

month = dec,

day = "1",

language = "English (US)",

pages = "31--34",

journal = "European Space Agency, (Special Publication) ESA SP",

issn = "0379-6566",

publisher = "European Space Agency",

number = "295",

note = "Proceedings of the 7th European Symposium on Materials and Fluid Sciences in Microgravity ; Conference date: 10-09-1989 Through 15-09-1989",

}

TY - JOUR

T1 - Protein crystal growth in microgravity

AU - DeLucas, L. J.

AU - Smith, C. D.

AU - Smith, H. W.

AU - Vijay-Kumar, S.

AU - Senadhi, S. E.

AU - Ealick, S. E.

AU - Bugg, C. E.

AU - Carter, D. C.

AU - Snyder, R. S.

AU - Weber, P. C.

AU - Salemme, F. R.

AU - Ohlendorf, D. H.

AU - Einspahr, H. M.

AU - Clancy, L. L.

AU - Navia, M. A.

AU - McKeever, B. M.

PY - 1989/12/1

Y1 - 1989/12/1

N2 - Crystal growth has become a major bottleneck in further development of protein crystallography. One promising area of research is protein crystal growth in the microgravity environment of space. A series of growth experiments were performed on U.S. shuttle flight STS-26 in September, 1988 and STS-29 in March, 1989. For those proteins which produced crystals of adequate size, three-dimensional intensity data sets with electronic area detector systems were collected. Comparisons of the microgravity-grown crystals with the best earth-grown crystals demonstrate that the microgravity-grown crystals are larger, display more uniform morphologies, and yield diffraction data to significantly higher resolutions.

AB - Crystal growth has become a major bottleneck in further development of protein crystallography. One promising area of research is protein crystal growth in the microgravity environment of space. A series of growth experiments were performed on U.S. shuttle flight STS-26 in September, 1988 and STS-29 in March, 1989. For those proteins which produced crystals of adequate size, three-dimensional intensity data sets with electronic area detector systems were collected. Comparisons of the microgravity-grown crystals with the best earth-grown crystals demonstrate that the microgravity-grown crystals are larger, display more uniform morphologies, and yield diffraction data to significantly higher resolutions.

UR - http://www.scopus.com/inward/record.url?scp=0024891274&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024891274&partnerID=8YFLogxK

M3 - Conference article

AN - SCOPUS:0024891274

SN - 0379-6566

SP - 31

EP - 34

JO - European Space Agency, (Special Publication) ESA SP

JF - European Space Agency, (Special Publication) ESA SP

IS - 295

T2 - Proceedings of the 7th European Symposium on Materials and Fluid Sciences in Microgravity

Y2 - 10 September 1989 through 15 September 1989

ER -

Protein crystal growth in microgravity

Abstract

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