Protein crystal growth in microgravity

L. J. DeLucas, C. D. Smith, H. W. Smith, S. Vijay-Kumar, S. E. Senadhi, S. E. Ealick, C. E. Bugg, D. C. Carter, R. S. Snyder, P. C. Weber, F. R. Salemme, D. H. Ohlendorf, H. M. Einspahr, L. L. Clancy, M. A. Navia, B. M. McKeever

Research output: Contribution to journalConference articlepeer-review

Abstract

Crystal growth has become a major bottleneck in further development of protein crystallography. One promising area of research is protein crystal growth in the microgravity environment of space. A series of growth experiments were performed on U.S. shuttle flight STS-26 in September, 1988 and STS-29 in March, 1989. For those proteins which produced crystals of adequate size, three-dimensional intensity data sets with electronic area detector systems were collected. Comparisons of the microgravity-grown crystals with the best earth-grown crystals demonstrate that the microgravity-grown crystals are larger, display more uniform morphologies, and yield diffraction data to significantly higher resolutions.

Original languageEnglish (US)
Pages (from-to)31-34
Number of pages4
JournalEuropean Space Agency, (Special Publication) ESA SP
Issue number295
StatePublished - Dec 1 1989
EventProceedings of the 7th European Symposium on Materials and Fluid Sciences in Microgravity - Oxford, Engl
Duration: Sep 10 1989Sep 15 1989

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