Protein crystal growth in microgravity

Lawrence J. DeLucas, Craig D. Smith, H. Wilson Smith, Senadhi Vijay-Kumar, Shobha E. Senadhi, Steven E. Ealick, Daniel C. Carter, Robert S. Snyder, Patricia C. Weber, F. Raymond Salemme, D. H. Ohlendorf, H. M. Einspahr, L. L. Clancy, Manuel A. Navia, Brian M. McKeever, T. L. Nagabhushan, George Nelson, A. Mcpherson, S. Koszelak, G. TaylorD. Stammers, K. Powell, G. Darby, Charles E. Bugg

Research output: Contribution to journalArticlepeer-review

149 Scopus citations

Abstract

The crystals of most proteins or other biological macromolecules are poorly ordered and diffract to lower resolutions than those observed for most crystals of simple organic and inorganic compounds. Crystallization in the microgravity environment of space may improve crystal quality by eliminating convection effects near growing crystal surfaces. A series of 11 different protein crystal growth experiments was performed on U.S. space shuttle flight STS-26 in September 1988. The microgravity-grown crystals of γ-interferon D 1, porcine elastase, and isocitrate lyase are larger, display more uniform morphologies, and yield diffraction data to significantly higher resolutions than the best crystals of these proteins grown on Earth.

Original languageEnglish (US)
Pages (from-to)651-654
Number of pages4
JournalScience
Volume246
Issue number4930
DOIs
StatePublished - 1989

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