Protein and energy metabolism in type 1 diabetes

Sadie L. Hebert, K. Sreekumaran Nair

Research output: Contribution to journalReview articlepeer-review

65 Scopus citations


Profound metabolic changes occur in people with type 1 diabetes mellitus during insulin deprivation. These include an increase in basal energy expenditure and reduced mitochondrial function. In addition, protein metabolism is significantly affected during insulin deprivation. A greater increase in whole-body protein breakdown than protein synthesis occurs resulting in a net protein loss. During insulin deprivation the splanchnic bed has a net protein accretion which accounts for the total increase in whole-body protein synthesis while muscle is in a net catabolic state.

Original languageEnglish (US)
Pages (from-to)13-17
Number of pages5
JournalClinical Nutrition
Issue number1
StatePublished - Feb 2010

Bibliographical note

Funding Information:
The studies are supported by grants from the National Institute of Health R01 DK41973 and UL1 RR02415-01.


  • Energy metabolism
  • Insulin
  • Mitochondria
  • Protein synthesis
  • Type 1 diabetes


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