Abstract
Profound metabolic changes occur in people with type 1 diabetes mellitus during insulin deprivation. These include an increase in basal energy expenditure and reduced mitochondrial function. In addition, protein metabolism is significantly affected during insulin deprivation. A greater increase in whole-body protein breakdown than protein synthesis occurs resulting in a net protein loss. During insulin deprivation the splanchnic bed has a net protein accretion which accounts for the total increase in whole-body protein synthesis while muscle is in a net catabolic state.
Original language | English (US) |
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Pages (from-to) | 13-17 |
Number of pages | 5 |
Journal | Clinical Nutrition |
Volume | 29 |
Issue number | 1 |
DOIs | |
State | Published - Feb 2010 |
Bibliographical note
Funding Information:The studies are supported by grants from the National Institute of Health R01 DK41973 and UL1 RR02415-01.
Keywords
- Energy metabolism
- Insulin
- Mitochondria
- Protein synthesis
- Type 1 diabetes