Protective effects of kaempferol (3,4′,5,7-tetrahydroxyflavone) against amyloid beta peptide (Aβ)-Induced neurotoxicity in ICR mice

Jae Kyeom Kim; Soo Jung Choi; Hong Yon Cho; Han Joon Hwang; Young Jun Kim; Seung Taik Lim; Chang Ju Kim; Hye Kyung Kim; Sabrina Peterson; Dong Hoon Shin

doi:10.1271/bbb.90585

Protective effects of kaempferol (3,4′,5,7-tetrahydroxyflavone) against amyloid beta peptide (Aβ)-Induced neurotoxicity in ICR mice

Jae Kyeom Kim, Soo Jung Choi, Hong Yon Cho, Han Joon Hwang, Young Jun Kim, Seung Taik Lim, Chang Ju Kim, Hye Kyung Kim, Sabrina Peterson, Dong Hoon Shin

Research output: Contribution to journal › Article › peer-review

84 Scopus citations

Abstract

To determine the effects of kaempferol, rat pheochromocytoma cells (PC12) and Institute of Cancer Research (ICR) mice were utilized as neuronal models. Using in vitro assays, kaempferol was shown to have protective effects against oxidative stress-induced cytotoxicity in PC12 cells. Administration of kaempferol also significantly reversed amyloid beta peptide (Aβ)- induced impaired performance in a Y-maze test. Taken altogether, the results reported here suggest that further investigation is warranted of the influence of kaempferol on pathways related to Alzheimer's disease.

Original language	English (US)
Pages (from-to)	397-401
Number of pages	5
Journal	Bioscience, Biotechnology and Biochemistry
Volume	74
Issue number	2
DOIs	https://doi.org/10.1271/bbb.90585
State	Published - 2010
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by a Korea University Grant (2009).

Keywords

Alzheimer's disease
Amyloid beta peptide
Kaempferol (3, 4′, 5, 7-tetrahydroxyflavone)
Oxidative stress

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1271/bbb.90585

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title = "Protective effects of kaempferol (3,4′,5,7-tetrahydroxyflavone) against amyloid beta peptide (Aβ)-Induced neurotoxicity in ICR mice",

abstract = "To determine the effects of kaempferol, rat pheochromocytoma cells (PC12) and Institute of Cancer Research (ICR) mice were utilized as neuronal models. Using in vitro assays, kaempferol was shown to have protective effects against oxidative stress-induced cytotoxicity in PC12 cells. Administration of kaempferol also significantly reversed amyloid beta peptide (Aβ)- induced impaired performance in a Y-maze test. Taken altogether, the results reported here suggest that further investigation is warranted of the influence of kaempferol on pathways related to Alzheimer's disease.",

keywords = "Alzheimer's disease, Amyloid beta peptide, Kaempferol (3, 4′, 5, 7-tetrahydroxyflavone), Oxidative stress",

author = "Kim, {Jae Kyeom} and Choi, {Soo Jung} and Cho, {Hong Yon} and Hwang, {Han Joon} and Kim, {Young Jun} and Lim, {Seung Taik} and Kim, {Chang Ju} and Kim, {Hye Kyung} and Sabrina Peterson and Shin, {Dong Hoon}",

note = "Funding Information: This work was supported by a Korea University Grant (2009).",

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doi = "10.1271/bbb.90585",

language = "English (US)",

volume = "74",

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journal = "Bioscience, Biotechnology and Biochemistry",

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T1 - Protective effects of kaempferol (3,4′,5,7-tetrahydroxyflavone) against amyloid beta peptide (Aβ)-Induced neurotoxicity in ICR mice

AU - Kim, Jae Kyeom

AU - Choi, Soo Jung

AU - Cho, Hong Yon

AU - Hwang, Han Joon

AU - Kim, Young Jun

AU - Lim, Seung Taik

AU - Kim, Chang Ju

AU - Kim, Hye Kyung

AU - Peterson, Sabrina

AU - Shin, Dong Hoon

N1 - Funding Information: This work was supported by a Korea University Grant (2009).

PY - 2010

Y1 - 2010

N2 - To determine the effects of kaempferol, rat pheochromocytoma cells (PC12) and Institute of Cancer Research (ICR) mice were utilized as neuronal models. Using in vitro assays, kaempferol was shown to have protective effects against oxidative stress-induced cytotoxicity in PC12 cells. Administration of kaempferol also significantly reversed amyloid beta peptide (Aβ)- induced impaired performance in a Y-maze test. Taken altogether, the results reported here suggest that further investigation is warranted of the influence of kaempferol on pathways related to Alzheimer's disease.

AB - To determine the effects of kaempferol, rat pheochromocytoma cells (PC12) and Institute of Cancer Research (ICR) mice were utilized as neuronal models. Using in vitro assays, kaempferol was shown to have protective effects against oxidative stress-induced cytotoxicity in PC12 cells. Administration of kaempferol also significantly reversed amyloid beta peptide (Aβ)- induced impaired performance in a Y-maze test. Taken altogether, the results reported here suggest that further investigation is warranted of the influence of kaempferol on pathways related to Alzheimer's disease.

KW - Alzheimer's disease

KW - Amyloid beta peptide

KW - Kaempferol (3, 4′, 5, 7-tetrahydroxyflavone)

KW - Oxidative stress

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SN - 0916-8451

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EP - 401

JO - Bioscience, Biotechnology and Biochemistry

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ER -

Protective effects of kaempferol (3,4′,5,7-tetrahydroxyflavone) against amyloid beta peptide (Aβ)-Induced neurotoxicity in ICR mice

Abstract

Bibliographical note

Keywords

UN SDGs

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