Protective effects of kaempferol (3,4′,5,7-tetrahydroxyflavone) against amyloid beta peptide (Aβ)-Induced neurotoxicity in ICR mice

Jae Kyeom Kim, Soo Jung Choi, Hong Yon Cho, Han Joon Hwang, Young Jun Kim, Seung Taik Lim, Chang Ju Kim, Hye Kyung Kim, Sabrina Peterson, Dong Hoon Shin

Research output: Contribution to journalArticlepeer-review

78 Scopus citations


To determine the effects of kaempferol, rat pheochromocytoma cells (PC12) and Institute of Cancer Research (ICR) mice were utilized as neuronal models. Using in vitro assays, kaempferol was shown to have protective effects against oxidative stress-induced cytotoxicity in PC12 cells. Administration of kaempferol also significantly reversed amyloid beta peptide (Aβ)- induced impaired performance in a Y-maze test. Taken altogether, the results reported here suggest that further investigation is warranted of the influence of kaempferol on pathways related to Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)397-401
Number of pages5
JournalBioscience, Biotechnology and Biochemistry
Issue number2
StatePublished - 2010
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by a Korea University Grant (2009).


  • Alzheimer's disease
  • Amyloid beta peptide
  • Kaempferol (3, 4′, 5, 7-tetrahydroxyflavone)
  • Oxidative stress


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