Protective effect of Cynodon dactylon against STZ induced hepatic injury in rats

Santosh Kumar Singh, Prashant Kumar Rai, Dolly Jaiswal, Devendra K. Rai, Bechan Sherma, Geeta Watal

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16 Scopus citations


The present study was designed to investigate the hepatoprotective effect of aqueous extract of Cynodon dactylon, widely used in India as a traditional treatment for diabetes mellitus. Male Albino Wistar rats (180-220 g) were administered with streptozotocin (STZ, 50 mg/kg) intraperitoneally to induce experimental diabetes. Alkaline phosphatase (ALKP), serum glutamate oxaioacetate transaminase (SG0T), serum glutamate pyruvate transaminase (SGPT), croatinine (CRTN) and total protein (TP), urine sugar (US) and total haemoglobin (Hb) were estimated at the beginning and after 14 days of treatment. Daily oral administration of aqueous extract of Cynodon dactylon suspended in distilled water at 500 mg/kg dose almost normalized various biochemical parameters. This suggests that Cynodon dactylon can be used as a hepatoprotective agent.

Original languageEnglish (US)
Pages (from-to)195-199
Number of pages5
JournalJournal of Ecophysiology and Occupational Health
Issue number3-4
StatePublished - Dec 2008
Externally publishedYes


  • Alkaline phosphatase
  • Creatinine
  • Cynodon dectylon
  • Serum glutamate pyruwate transminase
  • Serum glutanate oxaloacietate transminase


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