Proteases in malaria parasites - A phylogenomic perspective

Hong Cai, Rui Kuang, Jianying Gu, Yufeng Wang

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

Malaria continues to be one of the most devastating global health problems due to the high morbidity and mortality it causes in endemic regions. The search for new anti malarial targets is of high priority because of the increasing prevalence of drug resistance in malaria parasites. Malarial proteases constitute a class of promising therapeutic targets as they play important roles in the parasite life cycle and it is possible to design and screen for specific protease inhibitors. In this mini-review, we provide a phylogenomic overview of malarial proteases. An evolutionary perspective on the origin and divergence of these proteases will provide insights into the adaptive mechanisms of parasite growth, development, infection, and pathogenesis.

Original languageEnglish (US)
Pages (from-to)417-427
Number of pages11
JournalCurrent Genomics
Volume12
Issue number6
DOIs
StatePublished - Sep 2011

Keywords

  • Genomics
  • Malaria
  • Phylogenomics
  • Plasmodium
  • Protease
  • Remote homology detection
  • Systems biology
  • Target
  • Vaccine

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