Prostaglandins, glucose homeostasis, and diabetes mellitus.

R. P. Robertson

Research output: Contribution to journalReview article

17 Scopus citations

Abstract

Prostaglandins of the E series are implicated as regulators of glucose homeostasis because of their effects on glucose production and secretion of insulin and glucagon. PGE is postulated to play a role in the pathophysiology of insulin secretion in adult-onset (Type II) diabetes mellitus. Evidence supporting this hypothesis includes the demonstration that PGE inhibits glucose-induced acute insulin responses in normal humans. Moreover, drugs that inhibit synthesis of PGE improve abnormal insulin secretion in human subjects with Type II diabetes mellitus.

Original languageEnglish (US)
Pages (from-to)1-12
Number of pages12
JournalAnnual review of medicine
Volume34
DOIs
StatePublished - 1983

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