Prostaglandins, glucose homeostasis, and diabetes mellitus.

R. P. Robertson

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Prostaglandins of the E series are implicated as regulators of glucose homeostasis because of their effects on glucose production and secretion of insulin and glucagon. PGE is postulated to play a role in the pathophysiology of insulin secretion in adult-onset (Type II) diabetes mellitus. Evidence supporting this hypothesis includes the demonstration that PGE inhibits glucose-induced acute insulin responses in normal humans. Moreover, drugs that inhibit synthesis of PGE improve abnormal insulin secretion in human subjects with Type II diabetes mellitus.

Original languageEnglish (US)
Pages (from-to)1-12
Number of pages12
JournalAnnual review of medicine
StatePublished - 1983
Externally publishedYes


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