Angiotensin-(1-7) is a predominant metabolite of angiotensin I in brain tissue. Its neuromodulatory and prostaglandin (PG) synthesizing capabilities were investigated in the rabbit isolated vas deferens. This metabolite had no significant effect as a neuromodulator, however it increased PGE synthesis in the vasa deferentia with a potency equivalent to that of angiotensin II. The angiotensin-(1-7) has a unique spectrum of activity among the angiotensin peptides to selectively increase PG synthesis. It could be useful in defining the relevance of angiotensin-induced PG synthesis in various systems, particularly in neuronal tissue. Angiotensin-(1-7) potentially could be useful in defining angiotensin receptor subtypes, as well.
Bibliographical noteFunding Information:
This work was supported by grants from the Public Health Service (HL 34600 and HL-6835) and Biomedical Research Support Grant BRSG SO7 RR05896 from the National Institutes of Health. We thank Dr. Zimmerman for the generous donation of PGE antibody. The expert technical assistance of Deanna Himango and Jacob Dunlap is greatly appreciated.