Prostaglandin production in response to angiotensin-(1-7) in rabbit isolated vasa deferentia

George J Trachte, K. Meixner, C. M. Ferrario, M. C. Khosla

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

Angiotensin-(1-7) is a predominant metabolite of angiotensin I in brain tissue. Its neuromodulatory and prostaglandin (PG) synthesizing capabilities were investigated in the rabbit isolated vas deferens. This metabolite had no significant effect as a neuromodulator, however it increased PGE synthesis in the vasa deferentia with a potency equivalent to that of angiotensin II. The angiotensin-(1-7) has a unique spectrum of activity among the angiotensin peptides to selectively increase PG synthesis. It could be useful in defining the relevance of angiotensin-induced PG synthesis in various systems, particularly in neuronal tissue. Angiotensin-(1-7) potentially could be useful in defining angiotensin receptor subtypes, as well.

Original languageEnglish (US)
Pages (from-to)385-394
Number of pages10
JournalProstaglandins
Volume39
Issue number4
DOIs
StatePublished - Apr 1990

Fingerprint Dive into the research topics of 'Prostaglandin production in response to angiotensin-(1-7) in rabbit isolated vasa deferentia'. Together they form a unique fingerprint.

  • Cite this