Prostaglandin E1 in infants with pulmonary atresia

E. K. Weir, R. E. Matisonn, E. Losman, E. Chesler

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Infants with pulmonary atresia are frequently dependent upon the patency of the ductus arteriosus for adequate pulmonary blood flow. Endogenous production of a dilator prostaglandin probably maintains patency of the ductus in utero. Infusion of prostaglandin E1 (PGE1) 0,1 μg/kg/min was used in 6 infants with pulmonary atresia to increase pulmonary blood flow and systemic oxygenation. The infusion improved the clinical condition of the infants and diminished the degree of central cyanosis. In 3 cases serial measurement of systemic arterial oxygen tension showed a sustained increase. There were no deleterious side-effects. During cardiac catheterization and preparation for operation, PGE1 provides a valuable means of maintaining pulmonary blood flow in infants with pulmonary atresia and a ductus arteriosus.

Original languageEnglish (US)
Pages (from-to)700-702
Number of pages3
JournalSouth African Medical Journal
Issue number17
StatePublished - Jan 1 1978


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