Propranolol decreases proliferation of endothelial cells transformed by Kaposi's sarcoma-associated herpesvirus and induces lytic viral gene expression

Shane C McAllister, Ryan S. Hanson, Rory D. Manion

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Kaposi's sarcoma (KS) is common in Africa, but economic constraints hinder successful treatment in most patients. Propranolol, a generic β-adrenergic antagonist, decreased proliferation of KS-associated herpesvirus (KSHV)-infected cells. Downregulation of cyclin A2 and cyclin-dependent kinase 1 (CDK1) recapitulated this phenotype. Additionally, propranolol induced lytic gene expression in association with downregulation of CDK6. Thus, propranolol has diverse effects on KSHV-infected cells, and this generic drug has potential as a therapeutic agent for KS.

Original languageEnglish (US)
Pages (from-to)11144-11149
Number of pages6
JournalJournal of virology
Volume89
Issue number21
DOIs
StatePublished - Jan 1 2015

Fingerprint Dive into the research topics of 'Propranolol decreases proliferation of endothelial cells transformed by Kaposi's sarcoma-associated herpesvirus and induces lytic viral gene expression'. Together they form a unique fingerprint.

  • Cite this