Propranolol decreases proliferation of endothelial cells transformed by Kaposi's sarcoma-associated herpesvirus and induces lytic viral gene expression

Shane C McAllister, Ryan S. Hanson, Rory D. Manion

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Kaposi's sarcoma (KS) is common in Africa, but economic constraints hinder successful treatment in most patients. Propranolol, a generic β-adrenergic antagonist, decreased proliferation of KS-associated herpesvirus (KSHV)-infected cells. Downregulation of cyclin A2 and cyclin-dependent kinase 1 (CDK1) recapitulated this phenotype. Additionally, propranolol induced lytic gene expression in association with downregulation of CDK6. Thus, propranolol has diverse effects on KSHV-infected cells, and this generic drug has potential as a therapeutic agent for KS.

Original languageEnglish (US)
Pages (from-to)11144-11149
Number of pages6
JournalJournal of Virology
Volume89
Issue number21
DOIs
StatePublished - Jan 1 2015

Fingerprint

Human herpesvirus 8
Human Herpesvirus 8
propranolol
Viral Genes
Propranolol
endothelial cells
Endothelial Cells
Kaposi's Sarcoma
sarcoma
Gene Expression
gene expression
Cyclin A2
Down-Regulation
adrenergic antagonists
CDC2 Protein Kinase
Generic Drugs
Adrenergic Antagonists
cyclin-dependent kinase
Herpesviridae
cyclins

Cite this

Propranolol decreases proliferation of endothelial cells transformed by Kaposi's sarcoma-associated herpesvirus and induces lytic viral gene expression. / McAllister, Shane C; Hanson, Ryan S.; Manion, Rory D.

In: Journal of Virology, Vol. 89, No. 21, 01.01.2015, p. 11144-11149.

Research output: Contribution to journalArticle

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