Native bovine prothrombin was shown to have a circulatory half-life of 90 minutes when injected into the circulatory system of rats. Removal of sialic acid resulted in a circulatory half-life of only 9 minutes and further enzymatic degradation of the carbohydrate restored the circulatory half-life to more nearly that of intact prothrombin. These observations broaden the generality of this phenomenon displayed by some other glycoproteins and therefore the possibility that sialic acid may function in determining the circulatory life of glycoproteins.
|Original language||English (US)|
|Number of pages||6|
|Journal||Biochemical and Biophysical Research Communications|
|State||Published - Oct 1 1971|