Properties of asialo and aglycoprothrombin

Gary L Nelsestuen, J. W. Suttie

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Native bovine prothrombin was shown to have a circulatory half-life of 90 minutes when injected into the circulatory system of rats. Removal of sialic acid resulted in a circulatory half-life of only 9 minutes and further enzymatic degradation of the carbohydrate restored the circulatory half-life to more nearly that of intact prothrombin. These observations broaden the generality of this phenomenon displayed by some other glycoproteins and therefore the possibility that sialic acid may function in determining the circulatory life of glycoproteins.

Original languageEnglish (US)
Pages (from-to)198-203
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume45
Issue number1
DOIs
StatePublished - Oct 1 1971

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