Facing a myriad of sexual health problems today, health ministries are being compelled to develop comprehensive approaches to sexual health promotion. Recently, there have been several attempts to develop these strategies at national, regional, and global levels. One of the challenges of articulating strategies has been arriving at basic definitions of sex, sexuality, sexual health, and responsible sexual behavior. However, there is remarkable consistency throughout these recent documents. These documents call for leadership of the health sector to create better climates for discussion of sexuality, access to information and education about sexuality, prevention strategies, access to care, and more research in human sexuality and evaluation of programs designed to promote sexual health and responsible sexual behavior.