Prolonged neonatal-onset hyperinsulinism in the absence of predisposing factors

T. Gisslen, B. Nathan, T. Thompson, R. Rao

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

This patient series reports on prolonged hyperinsulinism in four newborn infants without characteristic perinatal risk factors. The condition presented with asymptomatic hypoglycemia soon after birth and was accompanied by inappropriately elevated plasma insulin levels and suppressed ketogenesis and lipolysis. Glucose infusion rates between 11 and 20 mg/kg/min were necessary for correction of hypoglycemia. Sustained euglycemia could be achieved only after starting diazoxide. In all infants, diazoxide could be weaned off within weeks without the recurrence of hypoglycemia. This case series illustrates the varied perinatal history and clinical course of prolonged neonatal-onset hyperinsulinism and highlights the importance of considering this condition in infants without typical predisposing factors.

Original languageEnglish (US)
Pages (from-to)59-64
Number of pages6
JournalJournal of Neonatal-Perinatal Medicine
Volume4
Issue number1
DOIs
StatePublished - Apr 5 2011

Keywords

  • Diazoxide
  • hyperinsulinism
  • hypoglycemia
  • infants
  • newborn

Fingerprint Dive into the research topics of 'Prolonged neonatal-onset hyperinsulinism in the absence of predisposing factors'. Together they form a unique fingerprint.

Cite this