Maintenance chemotherapy consisting of weekly oral 6-thioguanine and intramuscular cytosine arabinoside was administered to 24 adult patients with acute non-lymphocytic leukæmia in complete remission. The median duration of complete remission was 16.5 months, with 9 patients (38%) still in their first remission after 18-56 months. 33% of the patients have been in continuous remission for over 2 yr, 21% for over 3 yr, and 12.5% for over 4 yr. Median survival so far is 22.5 months. This maintenance regimen is well tolerated, is easily administered on an outpatient basis, and produces substantial numbers of long-term remissions.
Bibliographical noteFunding Information:
and Prof. A. Pinchera for helpful criticism. The National Pituitary Agency and the National Institute of Arthritis and Metabolic Diseases (U.S.A.) supplied human T.s.H. and T.S.H. antiserum, and Dr J. T. Visser (Rotterdam) provided us with specific T3 antiserum. The study was supported by grants from the Finnish Academy to M.J.K. and by a grant from the Red Heart Foundation of the Finnish Lion’s Organi- sation. The work was aided by research grants to A. K. from the U.S. Heart Association.National Heart and Lung Institute (HE04697) and the American