TY - JOUR
T1 - PROLONGED MAINTAINED REMISSIONS OF ADULT ACUTE NON-LYMPHOCYTIC LEUKAEMIA
AU - Peterson, Bruce A
AU - Bloomfield, Clara D.
PY - 1977/7/23
Y1 - 1977/7/23
N2 - Maintenance chemotherapy consisting of weekly oral 6-thioguanine and intramuscular cytosine arabinoside was administered to 24 adult patients with acute non-lymphocytic leukæmia in complete remission. The median duration of complete remission was 16.5 months, with 9 patients (38%) still in their first remission after 18-56 months. 33% of the patients have been in continuous remission for over 2 yr, 21% for over 3 yr, and 12.5% for over 4 yr. Median survival so far is 22.5 months. This maintenance regimen is well tolerated, is easily administered on an outpatient basis, and produces substantial numbers of long-term remissions.
AB - Maintenance chemotherapy consisting of weekly oral 6-thioguanine and intramuscular cytosine arabinoside was administered to 24 adult patients with acute non-lymphocytic leukæmia in complete remission. The median duration of complete remission was 16.5 months, with 9 patients (38%) still in their first remission after 18-56 months. 33% of the patients have been in continuous remission for over 2 yr, 21% for over 3 yr, and 12.5% for over 4 yr. Median survival so far is 22.5 months. This maintenance regimen is well tolerated, is easily administered on an outpatient basis, and produces substantial numbers of long-term remissions.
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U2 - 10.1016/S0140-6736(77)90178-7
DO - 10.1016/S0140-6736(77)90178-7
M3 - Article
C2 - 69780
AN - SCOPUS:0017407939
VL - 310
SP - 158
EP - 160
JO - The Lancet
JF - The Lancet
SN - 0140-6736
IS - 8030
ER -