Prolonged increase in blood pressure by a single oral dose of caffeine in mildly hypertensive men

Thomas L. Whitsett, William R. Lovallo, Mustafa Al’Absi, Gwendolyn A. Pincomb, Michael F. Wilso

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


Caffeine is known to raise blood pressure (BP). We examined a single oral dose of caffeine (3.3 mg/kg, equivalent to 2 to 3 cups of coffee) on BP in 18 hypertensive (HTN) and 12 age-matched, normotensive (NT) men for 3 h. Systolic BPs were significantly higher after caffeine for both groups (P <.001) for the entire 3 h. The HTN group showed persistent elevation in diastolic BP for 3 h, whereas the increment of diastolic BP became smaller in the NT group 90 min after caffeine ingestion. Our results suggest that caffeine consumption may affect both diagnosis and treatment of hypertension and abstinence from caffeine may be beneficial, especially for hypertensive individuals. Am J Hypertens 1994;7:755–758.

Original languageEnglish (US)
Pages (from-to)755-758
Number of pages4
JournalAmerican journal of hypertension
Issue number8
StatePublished - Aug 1994
Externally publishedYes

Bibliographical note

Funding Information:
Received February 24, 1994. Accepted April 4, 1994. From the Department of Medicine, State University of New York (BHS, MFW), and Millard Fillmore Hospitals (BHS, MFW), Buffalo, New York and the Departments of Medicine (TLW), and Psychiatry and Behavioral Sciences (WRL, MaA, GAP), University of Oklahoma Health Sciences Center, and the Veterans Affairs Medical Center (WRL, MaA, GAP), Oklahoma City, Oklahoma. This study was supported by the National Heart, Lung, and Blood Institute (HL-32050) and the Oklahoma Center for the Advancement of Science and Technology (HRO-060), and the Department of Veterans Affairs. Address correspondence and reprint requests to Bong Hee Sung, PhD, Department of Medicine, Millard Fillmore Hospitals, Gates Circle, Buffalo, NY 14209.


  • Caffeine
  • Hemodynamics
  • Hypertension


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