Prolongation of mouse and rat pancreatic islet cell allografts by adenosine deaminase inhibitors and adenine arabinoside

Caliann T. Lum; David E R Sutherland; William D. Payne; Phyllis Gorecki; Arthur J. Matas; John S. Najarian

doi:10.1016/0022-4804(80)90081-5

Prolongation of mouse and rat pancreatic islet cell allografts by adenosine deaminase inhibitors and adenine arabinoside

Caliann T. Lum
, David E R Sutherland
, William D. Payne
, Phyllis Gorecki
, Arthur J. Matas
, John S. Najarian

Surgery

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Two adenosine deaminase inhibitors, erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) and 2-deoxycoformycin (2dCF) were evaluated for immunosuppressive properties in mouse and rat pancreatic islet cell allograft models. In the mouse model, administration of EHNA alone prolonged the survival of islet allografts. In the rat, neither EHNA or 2dCF alone permitted islet allograft survival. However, 2dCF, in combination with the deoxyadenosine analog adenine arabinoside provided significant rat islet allograft survival during a limited 8-day period of study.

Original language	English (US)
Pages (from-to)	44-48
Number of pages	5
Journal	Journal of Surgical Research
Volume	28
Issue number	1
DOIs	https://doi.org/10.1016/0022-4804(80)90081-5
State	Published - Jan 1980

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Publisher link

10.1016/0022-4804(80)90081-5

Find It

Find It at U of M Libraries

Cite this

@article{26dfd9248f0244c788ef4b8a5b3b71d5,

title = "Prolongation of mouse and rat pancreatic islet cell allografts by adenosine deaminase inhibitors and adenine arabinoside",

abstract = "Two adenosine deaminase inhibitors, erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) and 2-deoxycoformycin (2dCF) were evaluated for immunosuppressive properties in mouse and rat pancreatic islet cell allograft models. In the mouse model, administration of EHNA alone prolonged the survival of islet allografts. In the rat, neither EHNA or 2dCF alone permitted islet allograft survival. However, 2dCF, in combination with the deoxyadenosine analog adenine arabinoside provided significant rat islet allograft survival during a limited 8-day period of study.",

author = "Lum, \{Caliann T.\} and Sutherland, \{David E R\} and Payne, \{William D.\} and Phyllis Gorecki and Matas, \{Arthur J.\} and Najarian, \{John S.\}",

year = "1980",

month = jan,

doi = "10.1016/0022-4804(80)90081-5",

language = "English (US)",

volume = "28",

pages = "44--48",

journal = "Journal of Surgical Research",

issn = "0022-4804",

publisher = "Academic Press Inc.",

number = "1",

}

TY - JOUR

T1 - Prolongation of mouse and rat pancreatic islet cell allografts by adenosine deaminase inhibitors and adenine arabinoside

AU - Lum, Caliann T.

AU - Sutherland, David E R

AU - Payne, William D.

AU - Gorecki, Phyllis

AU - Matas, Arthur J.

AU - Najarian, John S.

PY - 1980/1

Y1 - 1980/1

N2 - Two adenosine deaminase inhibitors, erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) and 2-deoxycoformycin (2dCF) were evaluated for immunosuppressive properties in mouse and rat pancreatic islet cell allograft models. In the mouse model, administration of EHNA alone prolonged the survival of islet allografts. In the rat, neither EHNA or 2dCF alone permitted islet allograft survival. However, 2dCF, in combination with the deoxyadenosine analog adenine arabinoside provided significant rat islet allograft survival during a limited 8-day period of study.

AB - Two adenosine deaminase inhibitors, erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) and 2-deoxycoformycin (2dCF) were evaluated for immunosuppressive properties in mouse and rat pancreatic islet cell allograft models. In the mouse model, administration of EHNA alone prolonged the survival of islet allografts. In the rat, neither EHNA or 2dCF alone permitted islet allograft survival. However, 2dCF, in combination with the deoxyadenosine analog adenine arabinoside provided significant rat islet allograft survival during a limited 8-day period of study.

UR - https://www.scopus.com/pages/publications/0018861409

UR - https://www.scopus.com/pages/publications/0018861409#tab=citedBy

U2 - 10.1016/0022-4804(80)90081-5

DO - 10.1016/0022-4804(80)90081-5

M3 - Article

C2 - 6767140

AN - SCOPUS:0018861409

SN - 0022-4804

VL - 28

SP - 44

EP - 48

JO - Journal of Surgical Research

JF - Journal of Surgical Research

IS - 1

ER -

Prolongation of mouse and rat pancreatic islet cell allografts by adenosine deaminase inhibitors and adenine arabinoside

Abstract

UN SDGs

Publisher link

Find It

Other files and links

Fingerprint

Cite this