Prolongation of mouse and rat pancreatic islet cell allografts by adenosine deaminase inhibitors and adenine arabinoside

Caliann T. Lum; David E R Sutherland; William D. Payne; Phyllis Gorecki; Arthur J. Matas; John S. Najarian

doi:10.1016/0022-4804(80)90081-5

Prolongation of mouse and rat pancreatic islet cell allografts by adenosine deaminase inhibitors and adenine arabinoside

Caliann T. Lum, David E R Sutherland, William D. Payne, Phyllis Gorecki, Arthur J. Matas, John S. Najarian

Surgery

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Abstract

Two adenosine deaminase inhibitors, erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) and 2-deoxycoformycin (2dCF) were evaluated for immunosuppressive properties in mouse and rat pancreatic islet cell allograft models. In the mouse model, administration of EHNA alone prolonged the survival of islet allografts. In the rat, neither EHNA or 2dCF alone permitted islet allograft survival. However, 2dCF, in combination with the deoxyadenosine analog adenine arabinoside provided significant rat islet allograft survival during a limited 8-day period of study.

Original language	English (US)
Pages (from-to)	44-48
Number of pages	5
Journal	Journal of Surgical Research
Volume	28
Issue number	1
DOIs	https://doi.org/10.1016/0022-4804(80)90081-5
State	Published - Jan 1980

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abstract = "Two adenosine deaminase inhibitors, erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) and 2-deoxycoformycin (2dCF) were evaluated for immunosuppressive properties in mouse and rat pancreatic islet cell allograft models. In the mouse model, administration of EHNA alone prolonged the survival of islet allografts. In the rat, neither EHNA or 2dCF alone permitted islet allograft survival. However, 2dCF, in combination with the deoxyadenosine analog adenine arabinoside provided significant rat islet allograft survival during a limited 8-day period of study.",

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AU - Lum, Caliann T.

AU - Sutherland, David E R

AU - Payne, William D.

AU - Gorecki, Phyllis

AU - Matas, Arthur J.

AU - Najarian, John S.

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AB - Two adenosine deaminase inhibitors, erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) and 2-deoxycoformycin (2dCF) were evaluated for immunosuppressive properties in mouse and rat pancreatic islet cell allograft models. In the mouse model, administration of EHNA alone prolonged the survival of islet allografts. In the rat, neither EHNA or 2dCF alone permitted islet allograft survival. However, 2dCF, in combination with the deoxyadenosine analog adenine arabinoside provided significant rat islet allograft survival during a limited 8-day period of study.

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Prolongation of mouse and rat pancreatic islet cell allografts by adenosine deaminase inhibitors and adenine arabinoside

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