Proline-catalyzed simple and efficient synthesis of 1,8-dioxo- decahydroacridines in aqueous ethanol medium

K. Venkatesan, Suresh S. Pujari, Kumar V. Srinivasan

Research output: Contribution to journalArticlepeer-review

94 Scopus citations

Abstract

Proline-catalyzed synthesis of 1,8-dioxo-decahydroacridines is achieved via one-pot, three-component condensation of aromatic aldehydes, cyclic diketone, and aryl amines in aqueous ethanol medium. This method offers the advantages of proceeding in neutral and mild conditions, giving high to excellent yields of acridines with easy workup procedure.

Original languageEnglish (US)
Pages (from-to)228-241
Number of pages14
JournalSynthetic Communications
Volume39
Issue number2
DOIs
StatePublished - Jan 2009
Externally publishedYes

Bibliographical note

Funding Information:
K.V. thanks University Grants Commission, New Delhi, for providing a research fellowship.

Keywords

  • 1,8-dioxodecahydroacridines
  • Aqueous media
  • One-pot MCR
  • Proline

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