Proliferative enteritis associated with Lawsonia intracellularis in a Japanese macaque (Macaca fuscata)

Maud Lafortune, James F.X. Wellehan, Elliott R. Jacobson, J. Mitchell Troutman, Connie J. Gebhart, Margaret S. Thompson

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


A 2.5-yr-old, intact male Japanese macaque (Macaca fuscata) was observed to have a thickened ileum during exploratory laparotomy. Lawsonia intracellularis-associated proliferative enteritis was diagnosed using histopathology (Warthin-Starry stain), immunohistochemistry, and polymerase chain reaction analysis of the ileal biopsy. The animal developed transient diarrhea and severe hypoproteinemia 16 days after surgery but recovered with intensive treatment using azithromycin. Given the fact that very specific tests are required for identifying this organism, L. intracellularis may be underdiagnosed in nonhuman primates.

Original languageEnglish (US)
Pages (from-to)549-552
Number of pages4
JournalJournal of Zoo and Wildlife Medicine
Issue number4
StatePublished - Dec 2004


  • Diarrhea
  • Japanese macaque
  • Lawsonia intracellularis
  • Macaca fuscata
  • Nonhuman primate
  • Proliferative enteropathy


Dive into the research topics of 'Proliferative enteritis associated with Lawsonia intracellularis in a Japanese macaque (Macaca fuscata)'. Together they form a unique fingerprint.

Cite this