TY - JOUR
T1 - Proliferative enteritis associated with Lawsonia intracellularis in a Japanese macaque (Macaca fuscata)
AU - Lafortune, Maud
AU - Wellehan, James F.X.
AU - Jacobson, Elliott R.
AU - Troutman, J. Mitchell
AU - Gebhart, Connie J.
AU - Thompson, Margaret S.
PY - 2004/12
Y1 - 2004/12
N2 - A 2.5-yr-old, intact male Japanese macaque (Macaca fuscata) was observed to have a thickened ileum during exploratory laparotomy. Lawsonia intracellularis-associated proliferative enteritis was diagnosed using histopathology (Warthin-Starry stain), immunohistochemistry, and polymerase chain reaction analysis of the ileal biopsy. The animal developed transient diarrhea and severe hypoproteinemia 16 days after surgery but recovered with intensive treatment using azithromycin. Given the fact that very specific tests are required for identifying this organism, L. intracellularis may be underdiagnosed in nonhuman primates.
AB - A 2.5-yr-old, intact male Japanese macaque (Macaca fuscata) was observed to have a thickened ileum during exploratory laparotomy. Lawsonia intracellularis-associated proliferative enteritis was diagnosed using histopathology (Warthin-Starry stain), immunohistochemistry, and polymerase chain reaction analysis of the ileal biopsy. The animal developed transient diarrhea and severe hypoproteinemia 16 days after surgery but recovered with intensive treatment using azithromycin. Given the fact that very specific tests are required for identifying this organism, L. intracellularis may be underdiagnosed in nonhuman primates.
KW - Diarrhea
KW - Japanese macaque
KW - Lawsonia intracellularis
KW - Macaca fuscata
KW - Nonhuman primate
KW - Proliferative enteropathy
UR - http://www.scopus.com/inward/record.url?scp=13244279733&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=13244279733&partnerID=8YFLogxK
U2 - 10.1638/03-080
DO - 10.1638/03-080
M3 - Article
C2 - 15732600
AN - SCOPUS:13244279733
SN - 1042-7260
VL - 35
SP - 549
EP - 552
JO - Journal of Zoo and Wildlife Medicine
JF - Journal of Zoo and Wildlife Medicine
IS - 4
ER -