Proliferating CD4+ T cells undergo immediate growth arrest upon cessation of TCR signaling in vivo

Cory A. Yarke, Stacy L. Dalheimer, Na Zhang, Drew M. Catron, Marc Jenkins, Daniel L Mueller

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

To investigate the role of TCR signaling in the exit of CD4+ T cells from cell cycle, we took advantage of a low frequency TEa T cell adoptive transfer technique as well as the Y-Ae mAb to interrupt Ag/MHC recognition before the completion of clonal expansion. Termination of TCR signaling after 36 h of Ag exposure caused an immediate reduction in cell size and deceleration of G1->SG2M phase cell cycle progression. As a consequence, clonal expansion in the absence of durable TCR signaling decreased by two-thirds. Thus, CD4+ T cells scan for the presence Ag throughout their clonal expansion response, and continuously adjust their rate of cell growth and G1->S phase transition to match their intensity of TCR signaling.

Original languageEnglish (US)
Pages (from-to)156-162
Number of pages7
JournalJournal of Immunology
Volume180
Issue number1
DOIs
StatePublished - Jan 1 2008

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