Progressive myoclonus epilepsy treated with zonisamide

Thomas R. Henry, Ilo E. Leppik, Robert J. Gumnit, Margaret Jacobs

Research output: Contribution to journalArticlepeer-review

96 Scopus citations

Abstract

Two patients with progressive myoclonus epilepsy of the Unvemcht-Lundborg type and with intractable seizures in spite of standard anticonvulsant regimens were treated with zonisamide. After zonisamide therapy was initiated, both had a marked decrease in seizure frequency and significant improvement of functioning. Serum zonisamide concentrations were 43 and 27 μg/ml, respectively, with doses of 8.8 and 10.5 mg/kg/d. Both patients also continue to receive valproic acid and a benzodiazepine.

Original languageEnglish (US)
Pages (from-to)928-931
Number of pages4
JournalNeurology
Volume38
Issue number6
DOIs
StatePublished - Jun 1988

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