Abstract
Two patients with progressive myoclonus epilepsy of the Unvemcht-Lundborg type and with intractable seizures in spite of standard anticonvulsant regimens were treated with zonisamide. After zonisamide therapy was initiated, both had a marked decrease in seizure frequency and significant improvement of functioning. Serum zonisamide concentrations were 43 and 27 μg/ml, respectively, with doses of 8.8 and 10.5 mg/kg/d. Both patients also continue to receive valproic acid and a benzodiazepine.
Original language | English (US) |
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Pages (from-to) | 928-931 |
Number of pages | 4 |
Journal | Neurology |
Volume | 38 |
Issue number | 6 |
DOIs | |
State | Published - Jun 1988 |