Progressive expression of PPARGC1α is associated with hair miniaturization in androgenetic alopecia

Bryan Siu Yin Ho, Candida Vaz, Srinivas Ramasamy, Elaine Guo Yan Chew, Jameelah Sheik Mohamed, Huma Jaffar, Axel Hillmer, Vivek Tanavde, Mei Bigliardi-Qi, Paul L Bigliardi

Research output: Contribution to journalArticle

Abstract

Current opinion views androgens as the pathogenic driver in the miniaturization of hair follicles of androgenetic alopecia by interfering with the dermal papilla. This cannot be the sole cause and therefore it is important for therapeutic and diagnostic purposes to identify additional pathways. Comparative full transcriptome profile analysis of the hair bulb region of normal and miniaturized hair follicles from vertex and occipital region in males with and without androgenetic alopecia revealed that next to the androgen receptor as well the retinoid receptor and particularly the PPAR pathway is involved in progressive hair miniaturization. We demonstrate the concurrent up-regulation of PPARGC1a in the epithelial compartment and androgen receptor in the dermal papilla of miniaturized hair. Dynamic Ppargc1a expression in the mouse hair cycle suggests a possible role in regulating hair growth and differentiation. This is supported by reduced proliferation of human dermal papilla and predominantly epithelial keratinocytes after incubation with AICAR, the agonist for AMPK signaling which activates PPARGC1a and serves as co-activator of PPARγ. In addition, miRNA profiling shows enrichment of miRNA-targeted genes in retinoid receptors and PPARGC1α/PPARγ signaling, and antigen presentation pathways.

Original languageEnglish (US)
Article number8771
JournalScientific reports
Volume9
Issue number1
DOIs
StatePublished - Dec 1 2019

Fingerprint

Miniaturization
Alopecia
Hair
Peroxisome Proliferator-Activated Receptors
Hair Follicle
Retinoids
Androgen Receptors
MicroRNAs
Skin
Occipital Lobe
AMP-Activated Protein Kinases
Antigen Presentation
Gene Expression Profiling
Keratinocytes
Transcriptome
Androgens
Up-Regulation
peroxisome-proliferator-activated receptor-gamma coactivator-1
Growth
Genes

PubMed: MeSH publication types

  • Journal Article

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Progressive expression of PPARGC1α is associated with hair miniaturization in androgenetic alopecia. / Ho, Bryan Siu Yin; Vaz, Candida; Ramasamy, Srinivas; Chew, Elaine Guo Yan; Mohamed, Jameelah Sheik; Jaffar, Huma; Hillmer, Axel; Tanavde, Vivek; Bigliardi-Qi, Mei; Bigliardi, Paul L.

In: Scientific reports, Vol. 9, No. 1, 8771, 01.12.2019.

Research output: Contribution to journalArticle

Ho, Bryan Siu Yin ; Vaz, Candida ; Ramasamy, Srinivas ; Chew, Elaine Guo Yan ; Mohamed, Jameelah Sheik ; Jaffar, Huma ; Hillmer, Axel ; Tanavde, Vivek ; Bigliardi-Qi, Mei ; Bigliardi, Paul L. / Progressive expression of PPARGC1α is associated with hair miniaturization in androgenetic alopecia. In: Scientific reports. 2019 ; Vol. 9, No. 1.
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