Progression of left ventricular diastolic dysfunction in ethnic minorities

Heather M. Prendergast, Samuel Dudley, John Kane, Martha Daviglus, Jared Marcucci, Anthony Acosta, E. Bradshaw Bunney, Dejuran Richardson, Tamara O'Neal

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: Approximately 50 % of heart failure cases are due to diastolic failure. Generally, it is thought that asymptomatic diastolic dysfunction precedes the development of diastolic heart failure, representing an ideal time for intervention. Previous studies have examined progression rates in non-minority populations only. Objective: To determine the rate of diastolic dysfunction progression and the associated risk factors in a predominately ethnic minority population. Design, Setting, and Participants: A retrospective cohort study of participants drawn from the echocardiogram database and Electronic Health Record (EHR) for an academic medical center. Individuals with 2 or more echocardiograms showing diastolic dysfunction during a six-year study period (2006-2012) were selected. Main Outcome Measures: Change in diastolic function grade over time and risk factors associated with this change. Results: During the six-year retrospective study period, 154 patients with 2 or more echocardiograms demonstrating diastolic dysfunction were reviewed; these represented 496 echocardiograms. The mean time between echocardiograms was 1.9 years. Mean age was 64.6 (±10.1) years, 81 % were female, and average BMI was 30.5(±7.4). The majority of subjects had Grade I diastolic dysfunction at the initial examination (87.7 % (n = 135)); 9 % (n = 14) had Grade II, and 3 % (n = 5) had Grade III. Approximately 27.9 % (n = 43) of the study cohort demonstrated overall worsening grade of diastolic dysfunction over time. Diastolic dysfunction grade was unchanged in 62 % (n = 96), improved in 9.7 % (n = 14), and worsened then improved in 0.7 % (n = 1). Conclusions: Our study showed a slightly higher rate of diastolic dysfunction progression in this predominately ethnic minority population. This is consistent with a previous study in a non-minority population demonstrating the progressive nature of diastolic dysfunction over time. Understanding the role of cardiovascular disease risk factors in accelerating progression rates from asymptomatic diastolic dysfunction to symptomatic stages is paramount to optimize intervention strategies.

Original languageEnglish (US)
Pages (from-to)205-211
Number of pages7
JournalHigh Blood Pressure and Cardiovascular Prevention
Volume21
Issue number3
DOIs
StatePublished - Sep 2014
Externally publishedYes

Bibliographical note

Funding Information:
Acknowledgment The project described was supported by the National Center for Advancing Translational Sciences, National Institutes of Health, through Grant UL1TR000050. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.

Keywords

  • Diastolic dysfunction
  • Ethnic minorities
  • Progression

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