Progression of diabetic nephropathy in type 1 diabetic patients

Behzad Najafian, Michael Mauer

Research output: Contribution to journalReview articlepeer-review

40 Scopus citations


Understanding pathogenetic mechanisms of diabetic nephropathy progression risk factors is important. Structural-functional relationship studies have increased our understanding of the glomerular, vascular and tubulointerstitial lesions evolution at various stages of diabetic nephropathy. Classical and more recently described lesions of diabetic nephropathy are discussed. Structural changes associated with progression toward proteinuria and GFR loss are summarized. The relationships of renal structure and function in diabetic nephropathy are best described by non-linear models which mimic the natural history of the disease, i.e., renal pathology develops in clinical silence but, once established, leads to proteinuria and GFR decline.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalDiabetes Research and Clinical Practice
Issue number1
StatePublished - Jan 2009

Bibliographical note

Copyright 2009 Elsevier B.V., All rights reserved.


  • Diabetic nephropathy
  • Human
  • Progression
  • Structural-functional relationships


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