Progression of diabetic nephropathy in type 1 diabetic patients

Behzad Najafian, Michael Mauer

Research output: Contribution to journalReview article

34 Citations (Scopus)

Abstract

Understanding pathogenetic mechanisms of diabetic nephropathy progression risk factors is important. Structural-functional relationship studies have increased our understanding of the glomerular, vascular and tubulointerstitial lesions evolution at various stages of diabetic nephropathy. Classical and more recently described lesions of diabetic nephropathy are discussed. Structural changes associated with progression toward proteinuria and GFR loss are summarized. The relationships of renal structure and function in diabetic nephropathy are best described by non-linear models which mimic the natural history of the disease, i.e., renal pathology develops in clinical silence but, once established, leads to proteinuria and GFR decline.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalDiabetes Research and Clinical Practice
Volume83
Issue number1
DOIs
StatePublished - Jan 1 2009

Fingerprint

Diabetic Nephropathies
Proteinuria
Kidney
Nonlinear Dynamics
Blood Vessels
Pathology

Keywords

  • Diabetic nephropathy
  • Human
  • Progression
  • Structural-functional relationships

Cite this

Progression of diabetic nephropathy in type 1 diabetic patients. / Najafian, Behzad; Mauer, Michael.

In: Diabetes Research and Clinical Practice, Vol. 83, No. 1, 01.01.2009, p. 1-8.

Research output: Contribution to journalReview article

@article{79a2229079ba477aa084ca7aa5575d63,
title = "Progression of diabetic nephropathy in type 1 diabetic patients",
abstract = "Understanding pathogenetic mechanisms of diabetic nephropathy progression risk factors is important. Structural-functional relationship studies have increased our understanding of the glomerular, vascular and tubulointerstitial lesions evolution at various stages of diabetic nephropathy. Classical and more recently described lesions of diabetic nephropathy are discussed. Structural changes associated with progression toward proteinuria and GFR loss are summarized. The relationships of renal structure and function in diabetic nephropathy are best described by non-linear models which mimic the natural history of the disease, i.e., renal pathology develops in clinical silence but, once established, leads to proteinuria and GFR decline.",
keywords = "Diabetic nephropathy, Human, Progression, Structural-functional relationships",
author = "Behzad Najafian and Michael Mauer",
year = "2009",
month = "1",
day = "1",
doi = "10.1016/j.diabres.2008.08.024",
language = "English (US)",
volume = "83",
pages = "1--8",
journal = "Diabetes Research and Clinical Practice",
issn = "0168-8227",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Progression of diabetic nephropathy in type 1 diabetic patients

AU - Najafian, Behzad

AU - Mauer, Michael

PY - 2009/1/1

Y1 - 2009/1/1

N2 - Understanding pathogenetic mechanisms of diabetic nephropathy progression risk factors is important. Structural-functional relationship studies have increased our understanding of the glomerular, vascular and tubulointerstitial lesions evolution at various stages of diabetic nephropathy. Classical and more recently described lesions of diabetic nephropathy are discussed. Structural changes associated with progression toward proteinuria and GFR loss are summarized. The relationships of renal structure and function in diabetic nephropathy are best described by non-linear models which mimic the natural history of the disease, i.e., renal pathology develops in clinical silence but, once established, leads to proteinuria and GFR decline.

AB - Understanding pathogenetic mechanisms of diabetic nephropathy progression risk factors is important. Structural-functional relationship studies have increased our understanding of the glomerular, vascular and tubulointerstitial lesions evolution at various stages of diabetic nephropathy. Classical and more recently described lesions of diabetic nephropathy are discussed. Structural changes associated with progression toward proteinuria and GFR loss are summarized. The relationships of renal structure and function in diabetic nephropathy are best described by non-linear models which mimic the natural history of the disease, i.e., renal pathology develops in clinical silence but, once established, leads to proteinuria and GFR decline.

KW - Diabetic nephropathy

KW - Human

KW - Progression

KW - Structural-functional relationships

UR - http://www.scopus.com/inward/record.url?scp=57949094883&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=57949094883&partnerID=8YFLogxK

U2 - 10.1016/j.diabres.2008.08.024

DO - 10.1016/j.diabres.2008.08.024

M3 - Review article

VL - 83

SP - 1

EP - 8

JO - Diabetes Research and Clinical Practice

JF - Diabetes Research and Clinical Practice

SN - 0168-8227

IS - 1

ER -