Abstract
Understanding pathogenetic mechanisms of diabetic nephropathy progression risk factors is important. Structural-functional relationship studies have increased our understanding of the glomerular, vascular and tubulointerstitial lesions evolution at various stages of diabetic nephropathy. Classical and more recently described lesions of diabetic nephropathy are discussed. Structural changes associated with progression toward proteinuria and GFR loss are summarized. The relationships of renal structure and function in diabetic nephropathy are best described by non-linear models which mimic the natural history of the disease, i.e., renal pathology develops in clinical silence but, once established, leads to proteinuria and GFR decline.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-8 |
| Number of pages | 8 |
| Journal | Diabetes Research and Clinical Practice |
| Volume | 83 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2009 |
Fingerprint
Keywords
- Diabetic nephropathy
- Human
- Progression
- Structural-functional relationships
Cite this
Progression of diabetic nephropathy in type 1 diabetic patients. / Najafian, Behzad; Mauer, Michael.
In: Diabetes Research and Clinical Practice, Vol. 83, No. 1, 01.01.2009, p. 1-8.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Progression of diabetic nephropathy in type 1 diabetic patients
AU - Najafian, Behzad
AU - Mauer, Michael
PY - 2009/1/1
Y1 - 2009/1/1
N2 - Understanding pathogenetic mechanisms of diabetic nephropathy progression risk factors is important. Structural-functional relationship studies have increased our understanding of the glomerular, vascular and tubulointerstitial lesions evolution at various stages of diabetic nephropathy. Classical and more recently described lesions of diabetic nephropathy are discussed. Structural changes associated with progression toward proteinuria and GFR loss are summarized. The relationships of renal structure and function in diabetic nephropathy are best described by non-linear models which mimic the natural history of the disease, i.e., renal pathology develops in clinical silence but, once established, leads to proteinuria and GFR decline.
AB - Understanding pathogenetic mechanisms of diabetic nephropathy progression risk factors is important. Structural-functional relationship studies have increased our understanding of the glomerular, vascular and tubulointerstitial lesions evolution at various stages of diabetic nephropathy. Classical and more recently described lesions of diabetic nephropathy are discussed. Structural changes associated with progression toward proteinuria and GFR loss are summarized. The relationships of renal structure and function in diabetic nephropathy are best described by non-linear models which mimic the natural history of the disease, i.e., renal pathology develops in clinical silence but, once established, leads to proteinuria and GFR decline.
KW - Diabetic nephropathy
KW - Human
KW - Progression
KW - Structural-functional relationships
UR - http://www.scopus.com/inward/record.url?scp=57949094883&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=57949094883&partnerID=8YFLogxK
U2 - 10.1016/j.diabres.2008.08.024
DO - 10.1016/j.diabres.2008.08.024
M3 - Review article
VL - 83
SP - 1
EP - 8
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
SN - 0168-8227
IS - 1
ER -