Progress towards understanding the genetic pathogenesis of systemic lupus erythematosus

Timothy W. Behrens, Robert R. Graham, Chieko Kyogoku, Emily C. Baechler, Paula S. Ramos, Clarence Gillett, Jason Bauer, Ward A. Ortmann, Keli L Hippen, Erik J Peterson, Carl D. Langefeld, Kathy L. Moser, Patrick M. Gaffney, Peter K. Gregersen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

13 Scopus citations

Abstract

In order to better understand the genetic factors that initiate systemic lupus erythematosus (SLE), we are using both linkage and association approaches to identify susceptibility genes for the disease. Association studies have recently identified three HLA Class II haplotypes as well as a functional missense polymorphism in protein tyrosine phosphatase (PTP) PTPN22 as important risk alleles for SLE. Here, we will review these data, and explain how these findings contribute to an understanding of the genetic architecture of human SLE.

Original languageEnglish (US)
Title of host publicationGenetics of Autoimmunity
Pages145-160
Number of pages16
StatePublished - Dec 1 2005

Publication series

NameNovartis Foundation Symposium
Volume267
ISSN (Print)1528-2511

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