Progress and challenges in understanding the regulation and function of p53 dynamics

Zhilin Yang, Ryan L. Hanson, Eric Batchelor

Research output: Contribution to journalReview articlepeer-review

Abstract

The dynamics of p53 expression provide a mechanism to increase differentiation between cellular stresses and specificity in appropriate responses. Here, we review recent advances in our understanding of the molecular mechanisms regulating p53 dynamics and the functions of the dynamics in the regulation of p53-dependent cell stress responses. We also compare dynamic encoding in the p53 system with that found in other important cell signaling systems, many of which can interact with the p53 network. Finally, we highlight some of the current challenges in understanding dynamic cell signaling within a larger cellular network context.

Original languageEnglish (US)
Pages (from-to)2123-2131
Number of pages9
JournalBiochemical Society transactions
Volume49
Issue number5
DOIs
StatePublished - Nov 2021

Bibliographical note

Funding Information:
This work was supported with startup funds from the University of Minnesota (EB).

Publisher Copyright:
© 2021 Portland Press Ltd. All rights reserved.

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't

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